Asymmetric addition of dimethylzinc to α-ketoesters catalyzed by (-)-MITH

Hsyueh Liang Wu; Ping Yu Wu; Ying Ying Shen; Biing Jiun Uang

doi:10.1021/jo801034q

Asymmetric addition of dimethylzinc to α-ketoesters catalyzed by (-)-MITH

Hsyueh Liang Wu, Ping Yu Wu, Ying Ying Shen, Biing Jiun Uang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

(Chemical Equation Presented) This investigation describes the catalytic asymmetric addition of dimethylzinc to α-ketoesters in the presence of (-)-MITH (5) and triethyl borate as an additive to give the corresponding chiral α-hydroxy esters with good yields and high enantioselectivities.

Original language	English
Pages (from-to)	6445-6447
Number of pages	3
Journal	Journal of Organic Chemistry
Volume	73
Issue number	16
DOIs	https://doi.org/10.1021/jo801034q
Publication status	Published - 2008 Aug 15
Externally published	Yes

ASJC Scopus subject areas

Organic Chemistry

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10.1021/jo801034q

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title = "Asymmetric addition of dimethylzinc to α-ketoesters catalyzed by (-)-MITH",

abstract = "(Chemical Equation Presented) This investigation describes the catalytic asymmetric addition of dimethylzinc to α-ketoesters in the presence of (-)-MITH (5) and triethyl borate as an additive to give the corresponding chiral α-hydroxy esters with good yields and high enantioselectivities.",

author = "Wu, {Hsyueh Liang} and Wu, {Ping Yu} and Shen, {Ying Ying} and Uang, {Biing Jiun}",

year = "2008",

month = aug,

day = "15",

doi = "10.1021/jo801034q",

language = "English",

volume = "73",

pages = "6445--6447",

journal = "Journal of Organic Chemistry",

issn = "0022-3263",

publisher = "American Chemical Society",

number = "16",

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T1 - Asymmetric addition of dimethylzinc to α-ketoesters catalyzed by (-)-MITH

AU - Wu, Hsyueh Liang

AU - Wu, Ping Yu

AU - Shen, Ying Ying

AU - Uang, Biing Jiun

PY - 2008/8/15

Y1 - 2008/8/15

N2 - (Chemical Equation Presented) This investigation describes the catalytic asymmetric addition of dimethylzinc to α-ketoesters in the presence of (-)-MITH (5) and triethyl borate as an additive to give the corresponding chiral α-hydroxy esters with good yields and high enantioselectivities.

AB - (Chemical Equation Presented) This investigation describes the catalytic asymmetric addition of dimethylzinc to α-ketoesters in the presence of (-)-MITH (5) and triethyl borate as an additive to give the corresponding chiral α-hydroxy esters with good yields and high enantioselectivities.

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U2 - 10.1021/jo801034q

DO - 10.1021/jo801034q

M3 - Article

C2 - 18646857

AN - SCOPUS:50149110222

SN - 0022-3263

VL - 73

SP - 6445

EP - 6447

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

IS - 16

ER -

Asymmetric addition of dimethylzinc to α-ketoesters catalyzed by (-)-MITH

Abstract

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