Asymmetric addition of dimethylzinc to α-ketoesters catalyzed by (-)-MITH

Hsyueh-Liang Wu, Ping Yu Wu, Ying Ying Shen, Biing Jiun Uang

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

(Chemical Equation Presented) This investigation describes the catalytic asymmetric addition of dimethylzinc to α-ketoesters in the presence of (-)-MITH (5) and triethyl borate as an additive to give the corresponding chiral α-hydroxy esters with good yields and high enantioselectivities.

Original languageEnglish
Pages (from-to)6445-6447
Number of pages3
JournalJournal of Organic Chemistry
Volume73
Issue number16
DOIs
Publication statusPublished - 2008 Aug 15

ASJC Scopus subject areas

  • Organic Chemistry

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