Asymmetric addition of diethylzinc to aldehydes catalyzed by a camphor-derived β-amino alcohol

Zhi Long Wu; Hsyueh Liang Wu; Ping Yu Wu; Biing Jiun Uang

doi:10.1016/j.tetasy.2009.06.009

Asymmetric addition of diethylzinc to aldehydes catalyzed by a camphor-derived β-amino alcohol

Zhi Long Wu, Hsyueh Liang Wu, Ping Yu Wu, Biing Jiun Uang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

The asymmetric addition of diethylzinc to aromatic and aliphatic aldehydes, including linear aliphatic ones, catalyzed by 2 mol % of β-amino alcohol (1S, 2R)-7,7-dimethyl-1-morpholin-4-yl-bicyclo[2.2.1]heptan-2-ol 10 gave the corresponding secondary alcohols in high yields and with up to 94% ee at ambient temperature after 15 min.

Original language	English
Pages (from-to)	1556-1560
Number of pages	5
Journal	Tetrahedron Asymmetry
Volume	20
Issue number	13
DOIs	https://doi.org/10.1016/j.tetasy.2009.06.009
Publication status	Published - 2009 Jul 16
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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title = "Asymmetric addition of diethylzinc to aldehydes catalyzed by a camphor-derived β-amino alcohol",

abstract = "The asymmetric addition of diethylzinc to aromatic and aliphatic aldehydes, including linear aliphatic ones, catalyzed by 2 mol % of β-amino alcohol (1S, 2R)-7,7-dimethyl-1-morpholin-4-yl-bicyclo[2.2.1]heptan-2-ol 10 gave the corresponding secondary alcohols in high yields and with up to 94% ee at ambient temperature after 15 min.",

author = "Wu, {Zhi Long} and Wu, {Hsyueh Liang} and Wu, {Ping Yu} and Uang, {Biing Jiun}",

note = "Funding Information: We thank the National Science Council, Republic of China, for the financial support.",

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doi = "10.1016/j.tetasy.2009.06.009",

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T1 - Asymmetric addition of diethylzinc to aldehydes catalyzed by a camphor-derived β-amino alcohol

AU - Wu, Zhi Long

AU - Wu, Hsyueh Liang

AU - Wu, Ping Yu

AU - Uang, Biing Jiun

N1 - Funding Information: We thank the National Science Council, Republic of China, for the financial support.

PY - 2009/7/16

Y1 - 2009/7/16

N2 - The asymmetric addition of diethylzinc to aromatic and aliphatic aldehydes, including linear aliphatic ones, catalyzed by 2 mol % of β-amino alcohol (1S, 2R)-7,7-dimethyl-1-morpholin-4-yl-bicyclo[2.2.1]heptan-2-ol 10 gave the corresponding secondary alcohols in high yields and with up to 94% ee at ambient temperature after 15 min.

AB - The asymmetric addition of diethylzinc to aromatic and aliphatic aldehydes, including linear aliphatic ones, catalyzed by 2 mol % of β-amino alcohol (1S, 2R)-7,7-dimethyl-1-morpholin-4-yl-bicyclo[2.2.1]heptan-2-ol 10 gave the corresponding secondary alcohols in high yields and with up to 94% ee at ambient temperature after 15 min.

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JF - Tetrahedron Asymmetry

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ER -

Asymmetric addition of diethylzinc to aldehydes catalyzed by a camphor-derived β-amino alcohol

Abstract

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