Asymmetric addition of diethylzinc to aldehydes catalyzed by a camphor-derived β-amino alcohol

Zhi Long Wu, Hsyueh Liang Wu, Ping Yu Wu, Biing Jiun Uang

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The asymmetric addition of diethylzinc to aromatic and aliphatic aldehydes, including linear aliphatic ones, catalyzed by 2 mol % of β-amino alcohol (1S, 2R)-7,7-dimethyl-1-morpholin-4-yl-bicyclo[2.2.1]heptan-2-ol 10 gave the corresponding secondary alcohols in high yields and with up to 94% ee at ambient temperature after 15 min.

Original languageEnglish
Pages (from-to)1556-1560
Number of pages5
JournalTetrahedron Asymmetry
Issue number13
Publication statusPublished - 2009 Jul 16


ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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