Abstract
Background: There is limited information regarding the associations of lifestyle factors and sex with HDL subclasses containing apolipoprotein (apo) A-I (Lp A-I) and both apo A-I and apo A-II (Lp A-I:A-II). Objective: We sought to examine the relations between 2 major HDL subclasses and sex, menopausal status, nutrient intakes, and adiposity. Design: We conducted interviews and measured blood variables in 409 government employees aged 40-59 y in Taiwan. Results: Women (n = 203) had significantly higher concentrations of HDL cholesterol, Lp A-I, and Lp A-I:A-II than did men (n = 206). Postmenopausal women (n = 72) had higher concentrations of HDL cholesterol, Lp A-I, and Lp A-I:A-II than did premenopausal women (n = 131). Body mass index and waist-to-hip ratio were strong predictors of and exerted an independent additive effect on Lp A-I concentrations in both men and women. However, body adiposity was associated with Lp A-I:A-II concentrations only in men. Waist-to-hip ratio was an independent determinant of Lp A-I but not of Lp A-I:A-II in men and postmenopausal women after adjustment for age, body mass index, smoking, and diet. Although there were relatively weak associations between dietary factors and both HDL subclasses (r = 0.01-0.26) in men and women according to bivariate analyses, multiple regression models showed that total fat, saturated fat, and cholesterol intakes were significantly correlated with HDL cholesterol and both Lp A-I and Lp A-I:A-II in men, but not in women. Conclusion: Our data suggest that body adiposity and dietary fat consumption affect 2 major HDL subclasses differently depending on subject sex and menopausal status.
Original language | English |
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Pages (from-to) | 64-71 |
Number of pages | 8 |
Journal | American Journal of Clinical Nutrition |
Volume | 74 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2001 |
Keywords
- Adiposity
- BMI
- Body fat
- Body mass index
- Cardiovascular disease
- Chinese population
- Diet
- Dietary fat
- HDL cholesterol
- HDL subclasses
- High-density-lipoprotein cholesterol
- Menopausal status
- Sex
- Taiwan
- Waist-to-hip ratio
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics