Association of sex, adiposity, and diet with HDL subclasses in middle-aged Chinese

Li Ching Lyu, Ching Ying Yeh, Alice H. Lichtenstein, Zhengling Li, Jose M. Ordovas, Ernst J. Schaefer

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background: There is limited information regarding the associations of lifestyle factors and sex with HDL subclasses containing apolipoprotein (apo) A-I (Lp A-I) and both apo A-I and apo A-II (Lp A-I:A-II). Objective: We sought to examine the relations between 2 major HDL subclasses and sex, menopausal status, nutrient intakes, and adiposity. Design: We conducted interviews and measured blood variables in 409 government employees aged 40-59 y in Taiwan. Results: Women (n = 203) had significantly higher concentrations of HDL cholesterol, Lp A-I, and Lp A-I:A-II than did men (n = 206). Postmenopausal women (n = 72) had higher concentrations of HDL cholesterol, Lp A-I, and Lp A-I:A-II than did premenopausal women (n = 131). Body mass index and waist-to-hip ratio were strong predictors of and exerted an independent additive effect on Lp A-I concentrations in both men and women. However, body adiposity was associated with Lp A-I:A-II concentrations only in men. Waist-to-hip ratio was an independent determinant of Lp A-I but not of Lp A-I:A-II in men and postmenopausal women after adjustment for age, body mass index, smoking, and diet. Although there were relatively weak associations between dietary factors and both HDL subclasses (r = 0.01-0.26) in men and women according to bivariate analyses, multiple regression models showed that total fat, saturated fat, and cholesterol intakes were significantly correlated with HDL cholesterol and both Lp A-I and Lp A-I:A-II in men, but not in women. Conclusion: Our data suggest that body adiposity and dietary fat consumption affect 2 major HDL subclasses differently depending on subject sex and menopausal status.

Original languageEnglish
Pages (from-to)64-71
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume74
Issue number1
Publication statusPublished - 2001

Fingerprint

middle-aged adults
Adiposity
adiposity
Diet
gender
diet
high density lipoprotein cholesterol
HDL2 Lipoprotein
HDL Cholesterol
apolipoprotein A-I
menopause
waist-to-hip ratio
Waist-Hip Ratio
Apolipoprotein A-I
body mass index
apolipoprotein A-II
Body Mass Index
Fats
Apolipoprotein A-II
Sex Factors

Keywords

  • Adiposity
  • BMI
  • Body fat
  • Body mass index
  • Cardiovascular disease
  • Chinese population
  • Diet
  • Dietary fat
  • HDL cholesterol
  • HDL subclasses
  • High-density-lipoprotein cholesterol
  • Menopausal status
  • Sex
  • Taiwan
  • Waist-to-hip ratio

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Lyu, L. C., Yeh, C. Y., Lichtenstein, A. H., Li, Z., Ordovas, J. M., & Schaefer, E. J. (2001). Association of sex, adiposity, and diet with HDL subclasses in middle-aged Chinese. American Journal of Clinical Nutrition, 74(1), 64-71.

Association of sex, adiposity, and diet with HDL subclasses in middle-aged Chinese. / Lyu, Li Ching; Yeh, Ching Ying; Lichtenstein, Alice H.; Li, Zhengling; Ordovas, Jose M.; Schaefer, Ernst J.

In: American Journal of Clinical Nutrition, Vol. 74, No. 1, 2001, p. 64-71.

Research output: Contribution to journalArticle

Lyu, LC, Yeh, CY, Lichtenstein, AH, Li, Z, Ordovas, JM & Schaefer, EJ 2001, 'Association of sex, adiposity, and diet with HDL subclasses in middle-aged Chinese', American Journal of Clinical Nutrition, vol. 74, no. 1, pp. 64-71.
Lyu, Li Ching ; Yeh, Ching Ying ; Lichtenstein, Alice H. ; Li, Zhengling ; Ordovas, Jose M. ; Schaefer, Ernst J. / Association of sex, adiposity, and diet with HDL subclasses in middle-aged Chinese. In: American Journal of Clinical Nutrition. 2001 ; Vol. 74, No. 1. pp. 64-71.
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abstract = "Background: There is limited information regarding the associations of lifestyle factors and sex with HDL subclasses containing apolipoprotein (apo) A-I (Lp A-I) and both apo A-I and apo A-II (Lp A-I:A-II). Objective: We sought to examine the relations between 2 major HDL subclasses and sex, menopausal status, nutrient intakes, and adiposity. Design: We conducted interviews and measured blood variables in 409 government employees aged 40-59 y in Taiwan. Results: Women (n = 203) had significantly higher concentrations of HDL cholesterol, Lp A-I, and Lp A-I:A-II than did men (n = 206). Postmenopausal women (n = 72) had higher concentrations of HDL cholesterol, Lp A-I, and Lp A-I:A-II than did premenopausal women (n = 131). Body mass index and waist-to-hip ratio were strong predictors of and exerted an independent additive effect on Lp A-I concentrations in both men and women. However, body adiposity was associated with Lp A-I:A-II concentrations only in men. Waist-to-hip ratio was an independent determinant of Lp A-I but not of Lp A-I:A-II in men and postmenopausal women after adjustment for age, body mass index, smoking, and diet. Although there were relatively weak associations between dietary factors and both HDL subclasses (r = 0.01-0.26) in men and women according to bivariate analyses, multiple regression models showed that total fat, saturated fat, and cholesterol intakes were significantly correlated with HDL cholesterol and both Lp A-I and Lp A-I:A-II in men, but not in women. Conclusion: Our data suggest that body adiposity and dietary fat consumption affect 2 major HDL subclasses differently depending on subject sex and menopausal status.",
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AU - Lyu, Li Ching

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AU - Lichtenstein, Alice H.

AU - Li, Zhengling

AU - Ordovas, Jose M.

AU - Schaefer, Ernst J.

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N2 - Background: There is limited information regarding the associations of lifestyle factors and sex with HDL subclasses containing apolipoprotein (apo) A-I (Lp A-I) and both apo A-I and apo A-II (Lp A-I:A-II). Objective: We sought to examine the relations between 2 major HDL subclasses and sex, menopausal status, nutrient intakes, and adiposity. Design: We conducted interviews and measured blood variables in 409 government employees aged 40-59 y in Taiwan. Results: Women (n = 203) had significantly higher concentrations of HDL cholesterol, Lp A-I, and Lp A-I:A-II than did men (n = 206). Postmenopausal women (n = 72) had higher concentrations of HDL cholesterol, Lp A-I, and Lp A-I:A-II than did premenopausal women (n = 131). Body mass index and waist-to-hip ratio were strong predictors of and exerted an independent additive effect on Lp A-I concentrations in both men and women. However, body adiposity was associated with Lp A-I:A-II concentrations only in men. Waist-to-hip ratio was an independent determinant of Lp A-I but not of Lp A-I:A-II in men and postmenopausal women after adjustment for age, body mass index, smoking, and diet. Although there were relatively weak associations between dietary factors and both HDL subclasses (r = 0.01-0.26) in men and women according to bivariate analyses, multiple regression models showed that total fat, saturated fat, and cholesterol intakes were significantly correlated with HDL cholesterol and both Lp A-I and Lp A-I:A-II in men, but not in women. Conclusion: Our data suggest that body adiposity and dietary fat consumption affect 2 major HDL subclasses differently depending on subject sex and menopausal status.

AB - Background: There is limited information regarding the associations of lifestyle factors and sex with HDL subclasses containing apolipoprotein (apo) A-I (Lp A-I) and both apo A-I and apo A-II (Lp A-I:A-II). Objective: We sought to examine the relations between 2 major HDL subclasses and sex, menopausal status, nutrient intakes, and adiposity. Design: We conducted interviews and measured blood variables in 409 government employees aged 40-59 y in Taiwan. Results: Women (n = 203) had significantly higher concentrations of HDL cholesterol, Lp A-I, and Lp A-I:A-II than did men (n = 206). Postmenopausal women (n = 72) had higher concentrations of HDL cholesterol, Lp A-I, and Lp A-I:A-II than did premenopausal women (n = 131). Body mass index and waist-to-hip ratio were strong predictors of and exerted an independent additive effect on Lp A-I concentrations in both men and women. However, body adiposity was associated with Lp A-I:A-II concentrations only in men. Waist-to-hip ratio was an independent determinant of Lp A-I but not of Lp A-I:A-II in men and postmenopausal women after adjustment for age, body mass index, smoking, and diet. Although there were relatively weak associations between dietary factors and both HDL subclasses (r = 0.01-0.26) in men and women according to bivariate analyses, multiple regression models showed that total fat, saturated fat, and cholesterol intakes were significantly correlated with HDL cholesterol and both Lp A-I and Lp A-I:A-II in men, but not in women. Conclusion: Our data suggest that body adiposity and dietary fat consumption affect 2 major HDL subclasses differently depending on subject sex and menopausal status.

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KW - HDL subclasses

KW - High-density-lipoprotein cholesterol

KW - Menopausal status

KW - Sex

KW - Taiwan

KW - Waist-to-hip ratio

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