Association of polymorphisms in genes involved in the dopaminergic pathway with blood pressure and uric acid levels in Chinese females

Ting-Kuang Yeh, Ting Chi Yeh, Chi Feng Weng, Bing Fu Shih, Hsueh Jen Tsao, Chien Hua Hsiao, Fu Tai Chuang, Chung Yi Hu, Chun-Yen Chang

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Since the high degree of heritability of physiological traits was demonstrated by twin and adoption studies, contemporary researchers in the fields of clinical medicine, behavioral science, and genetics have acknowledged the crucial role of genetic factors in human physiology. The study described herein explores the association between physiological parameters and the dopaminergic system using molecular genetic techniques. A total of 558 Taiwanese female volunteers, ranging from 16 to 17 years, were recruited. Single nucleotide polymorphisms in genes involved in the dopaminergic pathway were selected for analysis. Systolic blood pressure and diastolic blood pressure were associated significantly with the catechol-O-methyltransferase (COMT) Val158Met polymorphism and the dopamine β-hydroxylase (DBH) C1021T polymorphism. Furthermore, plasma uric acid was associated significantly with the COMT Val158Met polymorphism. Our study suggests the possible involvement of genetic polymorphisms in COMT and DBH in the regulation of blood pressure and plasma uric acid.

Original languageEnglish
Pages (from-to)1371-1376
Number of pages6
JournalJournal of Neural Transmission
Volume117
Issue number12
DOIs
Publication statusPublished - 2010 Dec 1

Fingerprint

Uric Acid
Catechol O-Methyltransferase
Blood Pressure
Genes
Behavioral Genetics
Behavioral Sciences
Genetic Techniques
Twin Studies
Clinical Medicine
Genetic Polymorphisms
Mixed Function Oxygenases
Single Nucleotide Polymorphism
Molecular Biology
Volunteers
Dopamine
Research Personnel

Keywords

  • Blood pressure
  • Dopaminergic pathway
  • Polymorphism
  • Uric acid

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Association of polymorphisms in genes involved in the dopaminergic pathway with blood pressure and uric acid levels in Chinese females. / Yeh, Ting-Kuang; Yeh, Ting Chi; Weng, Chi Feng; Shih, Bing Fu; Tsao, Hsueh Jen; Hsiao, Chien Hua; Chuang, Fu Tai; Hu, Chung Yi; Chang, Chun-Yen.

In: Journal of Neural Transmission, Vol. 117, No. 12, 01.12.2010, p. 1371-1376.

Research output: Contribution to journalArticle

Yeh, Ting-Kuang ; Yeh, Ting Chi ; Weng, Chi Feng ; Shih, Bing Fu ; Tsao, Hsueh Jen ; Hsiao, Chien Hua ; Chuang, Fu Tai ; Hu, Chung Yi ; Chang, Chun-Yen. / Association of polymorphisms in genes involved in the dopaminergic pathway with blood pressure and uric acid levels in Chinese females. In: Journal of Neural Transmission. 2010 ; Vol. 117, No. 12. pp. 1371-1376.
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