Association of apolipoprotein J polymorphism 1598delT with coronary artery disease and lipoprotein levels

Ju Pin Pan, Shu Liang Peter Wei, Shu Chiung Chiang, Guey-Jen Lee

Research output: Contribution to journalArticle

Abstract

Objectives: To investigate a polymorphism of the apolipoprotein J (APOJ) gene in relation to coronary artery disease (CAD) and lipid variables in a Chinese male population of genetically unrelated individuals. Methods: In this study, we recruited 126 control male subjects and 237 CAD male patients. CAD was defined as a fixed stenotic lesion with luminal narrowing ≥50% in at least one of the major or minor coronary arteries. In cases with documented myocardial infarction, only those rated as fully recovered for more than 3 months were enrolled. Patients with acute or chronic infectious diseases and those with malignancies were excluded. All subjects with a fasting serum triglyceride level higher than 300 mg/dl were likewise excluded. Results: We identified a single nucleotide polymorphism, 1598delT, and showed its association with CAD. Subjects with the I/I genotype showed a significantly higher CAD risk compared to those with the D/D genotype (OR 2.34, 95% CI 1.11-4.94, p = 0.026). Patients with the I/I genotype also had abnormal levels of high-density lipoprotein-cholesterol and low-density lipoprotein-cholesterol associated with CAD. Conclusions: Our data indicated that the APOJ single nucleotide polymorphism (1598delT) is associated with risk factors for CAD in a Chinese population.

Original languageEnglish
Pages (from-to)83-92
Number of pages10
JournalCardiology
Volume118
Issue number2
DOIs
Publication statusPublished - 2011 Jun 1

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Clusterin
Lipoproteins
Coronary Artery Disease
Genotype
Single Nucleotide Polymorphism
LDL Cholesterol
HDL Cholesterol
Population
Communicable Diseases
Fasting
Coronary Vessels
Triglycerides
Chronic Disease
Myocardial Infarction
Lipids
Serum

Keywords

  • Apolipoprotein J
  • Coronary artery disease
  • High-density lipoprotein cholesterol
  • Single-stranded conformational polymorphism

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

Cite this

Association of apolipoprotein J polymorphism 1598delT with coronary artery disease and lipoprotein levels. / Pan, Ju Pin; Wei, Shu Liang Peter; Chiang, Shu Chiung; Lee, Guey-Jen.

In: Cardiology, Vol. 118, No. 2, 01.06.2011, p. 83-92.

Research output: Contribution to journalArticle

Pan, Ju Pin ; Wei, Shu Liang Peter ; Chiang, Shu Chiung ; Lee, Guey-Jen. / Association of apolipoprotein J polymorphism 1598delT with coronary artery disease and lipoprotein levels. In: Cardiology. 2011 ; Vol. 118, No. 2. pp. 83-92.
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