Association between herpes zoster and end stage renal disease entrance in chronic kidney disease patients: a population-based cohort study

S. Y. Lin; J. H. Liu; H. C. Yeh; C. L. Lin; I. J. Tsai; P. C. Chen; F. C. Sung; Y. F. Yang; C. C. Huang; D. E. Morisky; Y. J. Chang; C. H. Kao

doi:10.1007/s10096-014-2143-6

Association between herpes zoster and end stage renal disease entrance in chronic kidney disease patients: a population-based cohort study

S. Y. Lin, J. H. Liu, H. C. Yeh, C. L. Lin, I. J. Tsai, P. C. Chen, F. C. Sung, Y. F. Yang, C. C. Huang, D. E. Morisky, Y. J. Chang, C. H. Kao^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The association between herpes zoster (HZ) infection and subsequent risk of end stage renal disease (ESRD) in chronic kidney disease (CKD) patients is unknown. We aim to conduct a population-based cohort study to investigate the risks of developing ESRD after a HZ attack in CKD patients. From the Taiwan National Health Insurance Research Database, we identified 1,144 CKD patients who had HZ over the period 1997–2008 as HZ cohort. We selected 3,855 age- and sex–matched CKD patients without HZ as comparison cohort. All subjects were followed until the end of 2008 or censored. Cox-proportional hazard regression model was used to estimate the effects of HZ on ESRD risks. A total of 396 patients developed ESRD during the follow-up period, of which 108 subjects were from the HZ cohort and 288 from the comparison cohort. The log–rank test demonstrated that the HZ cohort had significantly higher risk of developing ESRD than the comparison cohort (P = 0.0071). The adjusted hazard ratio of subsequent ESRD in the HZ cohort was 1.36 (95 % CI 1.09–1.70) and the hazard ratio increased to 8.71 (95 % CI 5.23–14.5) if the HZ cohort was with concomitant diabetes and hypertension. CKD patients with HZ are at an increased risk of subsequent ESRD. CKD patients with HZ, diabetes, and hypertension have extremely high risk of developing ESRD.

Original language	English
Pages (from-to)	1809-1815
Number of pages	7
Journal	European Journal of Clinical Microbiology and Infectious Diseases
Volume	33
Issue number	10
DOIs	https://doi.org/10.1007/s10096-014-2143-6
Publication status	Published - 2014 Oct 2
Externally published	Yes

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10096-014-2143-6

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Lin, S. Y., Liu, J. H., Yeh, H. C., Lin, C. L., Tsai, I. J., Chen, P. C., Sung, F. C., Yang, Y. F., Huang, C. C., Morisky, D. E., Chang, Y. J., & Kao, C. H. (2014). Association between herpes zoster and end stage renal disease entrance in chronic kidney disease patients: a population-based cohort study. European Journal of Clinical Microbiology and Infectious Diseases, 33(10), 1809-1815. https://doi.org/10.1007/s10096-014-2143-6

Lin, SY, Liu, JH, Yeh, HC, Lin, CL, Tsai, IJ, Chen, PC, Sung, FC, Yang, YF, Huang, CC, Morisky, DE, Chang, YJ & Kao, CH 2014, 'Association between herpes zoster and end stage renal disease entrance in chronic kidney disease patients: a population-based cohort study', European Journal of Clinical Microbiology and Infectious Diseases, vol. 33, no. 10, pp. 1809-1815. https://doi.org/10.1007/s10096-014-2143-6

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title = "Association between herpes zoster and end stage renal disease entrance in chronic kidney disease patients: a population-based cohort study",

abstract = "The association between herpes zoster (HZ) infection and subsequent risk of end stage renal disease (ESRD) in chronic kidney disease (CKD) patients is unknown. We aim to conduct a population-based cohort study to investigate the risks of developing ESRD after a HZ attack in CKD patients. From the Taiwan National Health Insurance Research Database, we identified 1,144 CKD patients who had HZ over the period 1997–2008 as HZ cohort. We selected 3,855 age- and sex–matched CKD patients without HZ as comparison cohort. All subjects were followed until the end of 2008 or censored. Cox-proportional hazard regression model was used to estimate the effects of HZ on ESRD risks. A total of 396 patients developed ESRD during the follow-up period, of which 108 subjects were from the HZ cohort and 288 from the comparison cohort. The log–rank test demonstrated that the HZ cohort had significantly higher risk of developing ESRD than the comparison cohort (P = 0.0071). The adjusted hazard ratio of subsequent ESRD in the HZ cohort was 1.36 (95 % CI 1.09–1.70) and the hazard ratio increased to 8.71 (95 % CI 5.23–14.5) if the HZ cohort was with concomitant diabetes and hypertension. CKD patients with HZ are at an increased risk of subsequent ESRD. CKD patients with HZ, diabetes, and hypertension have extremely high risk of developing ESRD.",

author = "Lin, {S. Y.} and Liu, {J. H.} and Yeh, {H. C.} and Lin, {C. L.} and Tsai, {I. J.} and Chen, {P. C.} and Sung, {F. C.} and Yang, {Y. F.} and Huang, {C. C.} and Morisky, {D. E.} and Chang, {Y. J.} and Kao, {C. H.}",

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doi = "10.1007/s10096-014-2143-6",

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T1 - Association between herpes zoster and end stage renal disease entrance in chronic kidney disease patients

T2 - a population-based cohort study

AU - Lin, S. Y.

AU - Liu, J. H.

AU - Yeh, H. C.

AU - Lin, C. L.

AU - Tsai, I. J.

AU - Chen, P. C.

AU - Sung, F. C.

AU - Yang, Y. F.

AU - Huang, C. C.

AU - Morisky, D. E.

AU - Chang, Y. J.

AU - Kao, C. H.

PY - 2014/10/2

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N2 - The association between herpes zoster (HZ) infection and subsequent risk of end stage renal disease (ESRD) in chronic kidney disease (CKD) patients is unknown. We aim to conduct a population-based cohort study to investigate the risks of developing ESRD after a HZ attack in CKD patients. From the Taiwan National Health Insurance Research Database, we identified 1,144 CKD patients who had HZ over the period 1997–2008 as HZ cohort. We selected 3,855 age- and sex–matched CKD patients without HZ as comparison cohort. All subjects were followed until the end of 2008 or censored. Cox-proportional hazard regression model was used to estimate the effects of HZ on ESRD risks. A total of 396 patients developed ESRD during the follow-up period, of which 108 subjects were from the HZ cohort and 288 from the comparison cohort. The log–rank test demonstrated that the HZ cohort had significantly higher risk of developing ESRD than the comparison cohort (P = 0.0071). The adjusted hazard ratio of subsequent ESRD in the HZ cohort was 1.36 (95 % CI 1.09–1.70) and the hazard ratio increased to 8.71 (95 % CI 5.23–14.5) if the HZ cohort was with concomitant diabetes and hypertension. CKD patients with HZ are at an increased risk of subsequent ESRD. CKD patients with HZ, diabetes, and hypertension have extremely high risk of developing ESRD.

AB - The association between herpes zoster (HZ) infection and subsequent risk of end stage renal disease (ESRD) in chronic kidney disease (CKD) patients is unknown. We aim to conduct a population-based cohort study to investigate the risks of developing ESRD after a HZ attack in CKD patients. From the Taiwan National Health Insurance Research Database, we identified 1,144 CKD patients who had HZ over the period 1997–2008 as HZ cohort. We selected 3,855 age- and sex–matched CKD patients without HZ as comparison cohort. All subjects were followed until the end of 2008 or censored. Cox-proportional hazard regression model was used to estimate the effects of HZ on ESRD risks. A total of 396 patients developed ESRD during the follow-up period, of which 108 subjects were from the HZ cohort and 288 from the comparison cohort. The log–rank test demonstrated that the HZ cohort had significantly higher risk of developing ESRD than the comparison cohort (P = 0.0071). The adjusted hazard ratio of subsequent ESRD in the HZ cohort was 1.36 (95 % CI 1.09–1.70) and the hazard ratio increased to 8.71 (95 % CI 5.23–14.5) if the HZ cohort was with concomitant diabetes and hypertension. CKD patients with HZ are at an increased risk of subsequent ESRD. CKD patients with HZ, diabetes, and hypertension have extremely high risk of developing ESRD.

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ER -

Association between herpes zoster and end stage renal disease entrance in chronic kidney disease patients: a population-based cohort study

Abstract

ASJC Scopus subject areas

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