Arginine vasopressin produces inhibition upon respiration without pressor effect in the rat

Ching Wen Chuang, Meng Tzu Cheng, Jin Tun Lin, Hsin Yun Hsien, Hzi Yu Hung, Ji Chuu Hwang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


The purpose of the current study was to examine where arginine vasopressin (AVP) inhibits respiration by direct action on the areas of the ventrolateral medulla (VLM) in the rat. The animal was anesthetized by urethane (1.2 g/kg, i.p.), paralyzed with gallamine triethiodide, and artificially ventilated. Catheterization of the femoral artery and vein, and bilateral vagotomy were performed. The rat was then placed upon a stereotaxic instrument in a prone position. The phrenic nerve was separated and cut peripherally. Phrenic nerve activity (PNA) was monitored at normocapnia and hypercapnia in hyperoxia. Microinjection of AVP into various subregions of the VLM was then performed. In response to AVP microinjection, a transient period of apnea and then a significant decrease in PNA amplitude were observed. Arterial blood pressure was unchanged. This inhibition of PNA with AVP treatment was site-specific, attenuated by raising CO 2 concentration, and totally abolished by pretreatment with AVP V 1A receptor antagonist. Data of the present study indicate that endogenous resource of AVP may produce an inhibitory effect upon respiration via AVP receptors presented on neurons within the VLM.

Original languageEnglish
Pages (from-to)71-81
Number of pages11
JournalChinese Journal of Physiology
Issue number2
Publication statusPublished - 2003 Jun 30


  • Arginine vasopressin
  • AVP V receptor antagonist
  • Phrenic review activity
  • Rat
  • Ventrolateral medulla

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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