Applications of Hadamard transform-gas chromatography/mass spectrometry for the detection of hexamethyldisiloxane in a wafer cleanroom

Yuan Kai Cheng, Cheng-Huang Lin, Samuel Kuo, Jonathan Yang, Szu Yuan Hsiung, Jia Lin Wang

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The Hadamard transform-gas chromatography/mass spectrometry (HT-GC/MS) technique was successfully employed for the detection of hexamethyldisiloxane (HMDSO, C6H18OSi2) at the sub-nL/L level in a semiconductor wafer cleanroom. Indoor air samples were collected from the room, according to EPA Method TO-17 using a Tedlar bag where the air samples were allowed to pass through an absorption tube for 24h. The condensed components were then heated and simultaneously injected into a GC column through a Hadamard-injector, which was operated in accordance with the Hadamard codes. Compared to the single injection used in most GC/MS systems, the signal-to-noise (S/N) ratios were substantially improved after the inverse Hadamard transformation of the encoded chromatogram. Under optimized conditions, when cyclic S-matrix orders of 255, 1023 and 2047 were used, the S/N ratios of the HMDSO signals were substantially improved by 7.4-, 15.1- and 20.1-fold, respectively. These improvements are in good agreement with theoretically calculated values (8.0-, 16.0- and 22.6-fold, respectively). We found that when the HT-GC/MS technique was applied, HMDSO could be detected at the 0.1nL/L level.

Original languageEnglish
Pages (from-to)143-146
Number of pages4
JournalJournal of Chromatography A
Volume1220
DOIs
Publication statusPublished - 2012 Jan 13

Fingerprint

Hadamard transforms
Signal-To-Noise Ratio
Gas chromatography
Gas Chromatography-Mass Spectrometry
Mass spectrometry
Signal to noise ratio
Air Bags
Semiconductors
Polyethylene Terephthalates
Air
Semiconductor materials
Injections
hexamethyldisiloxane

Keywords

  • AMC (airborne molecular contaminant)
  • Cleanroom
  • Gas chromatography/mass spectrometry
  • HMDS
  • HMDSO
  • Hadamard transform

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

Cite this

Applications of Hadamard transform-gas chromatography/mass spectrometry for the detection of hexamethyldisiloxane in a wafer cleanroom. / Cheng, Yuan Kai; Lin, Cheng-Huang; Kuo, Samuel; Yang, Jonathan; Hsiung, Szu Yuan; Wang, Jia Lin.

In: Journal of Chromatography A, Vol. 1220, 13.01.2012, p. 143-146.

Research output: Contribution to journalArticle

Cheng, Yuan Kai ; Lin, Cheng-Huang ; Kuo, Samuel ; Yang, Jonathan ; Hsiung, Szu Yuan ; Wang, Jia Lin. / Applications of Hadamard transform-gas chromatography/mass spectrometry for the detection of hexamethyldisiloxane in a wafer cleanroom. In: Journal of Chromatography A. 2012 ; Vol. 1220. pp. 143-146.
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