Application of an OLED integrated with BEF and giant birefringent optical (GBO) film in a SPR biosensor

Briliant Adhi Prabowo; Ying Feng Chang; Yu Ying Lee; Li Chen Su; Chih Jen Yu; Yen Heng Lin; Chien Chou; Nan Fu Chiu; Hsin Chih Lai; Kou Chen Liu

doi:10.1016/j.snb.2014.03.041

Application of an OLED integrated with BEF and giant birefringent optical (GBO) film in a SPR biosensor

Briliant Adhi Prabowo, Ying Feng Chang, Yu Ying Lee, Li Chen Su, Chih Jen Yu, Yen Heng Lin, Chien Chou, Nan Fu Chiu, Hsin Chih Lai^*, Kou Chen Liu

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

This study aims to improve the signal sensitivity of a portable surface plasmon resonance (SPR) sensor system. An organic light emitting diode (OLED) was integrated with a brightness enhancement film (BEF) and a giant birefringent optical (GBO) film as a light source to construct the SPR based on an OLED-BEF-GBO film. A method for calculating the SPR signal by summing the differences in optical intensity at two different wavelengths was used to minimize the effect of the noise error that particularly occurs in a portable SPR device. The experimental results indicated that the limit of detection (LOD) of the SPR using an Au sensing layer has an effective refractive index change of 7.8 × 10^-6 RIU. Furthermore, for the SPR using Au/Ag sensing metal layers, an LOD of 3.2 × 10^-6 RIU was achieved due to the improved sensitivity and resolution value compared with the use of an Au sensing layer. The use of the SPR device in a bio-affinity assay to test the interaction between goat anti-mouse immunoglobulin G (IgG) and mouse IgG protein achieved a LOD of approximately 40.6 pg/mL.

Original language	English
Pages (from-to)	424-430
Number of pages	7
Journal	Sensors and Actuators, B: Chemical
Volume	198
DOIs	https://doi.org/10.1016/j.snb.2014.03.041
Publication status	Published - 2014 Jul 31

Keywords

Biosensor
Brightness enhancement film (BEF)
GBO film
Organic light emitting diode (OLED)
Surface plasmon resonance (SPR)

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Instrumentation
Condensed Matter Physics
Surfaces, Coatings and Films
Metals and Alloys
Electrical and Electronic Engineering
Materials Chemistry

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10.1016/j.snb.2014.03.041

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title = "Application of an OLED integrated with BEF and giant birefringent optical (GBO) film in a SPR biosensor",

abstract = "This study aims to improve the signal sensitivity of a portable surface plasmon resonance (SPR) sensor system. An organic light emitting diode (OLED) was integrated with a brightness enhancement film (BEF) and a giant birefringent optical (GBO) film as a light source to construct the SPR based on an OLED-BEF-GBO film. A method for calculating the SPR signal by summing the differences in optical intensity at two different wavelengths was used to minimize the effect of the noise error that particularly occurs in a portable SPR device. The experimental results indicated that the limit of detection (LOD) of the SPR using an Au sensing layer has an effective refractive index change of 7.8 × 10-6 RIU. Furthermore, for the SPR using Au/Ag sensing metal layers, an LOD of 3.2 × 10-6 RIU was achieved due to the improved sensitivity and resolution value compared with the use of an Au sensing layer. The use of the SPR device in a bio-affinity assay to test the interaction between goat anti-mouse immunoglobulin G (IgG) and mouse IgG protein achieved a LOD of approximately 40.6 pg/mL.",

keywords = "Biosensor, Brightness enhancement film (BEF), GBO film, Organic light emitting diode (OLED), Surface plasmon resonance (SPR)",

author = "Prabowo, {Briliant Adhi} and Chang, {Ying Feng} and Lee, {Yu Ying} and Su, {Li Chen} and Yu, {Chih Jen} and Lin, {Yen Heng} and Chien Chou and Chiu, {Nan Fu} and Lai, {Hsin Chih} and Liu, {Kou Chen}",

note = "Funding Information: This research is supported and funded by the Taiwan NSC 10-0232-5B18-2006 and Taiwan NRPB 10-0IDP-1008-2 . ",

year = "2014",

month = jul,

day = "31",

doi = "10.1016/j.snb.2014.03.041",

language = "English",

volume = "198",

pages = "424--430",

journal = "Sensors and Actuators, B: Chemical",

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TY - JOUR

T1 - Application of an OLED integrated with BEF and giant birefringent optical (GBO) film in a SPR biosensor

AU - Prabowo, Briliant Adhi

AU - Chang, Ying Feng

AU - Lee, Yu Ying

AU - Su, Li Chen

AU - Yu, Chih Jen

AU - Lin, Yen Heng

AU - Chou, Chien

AU - Chiu, Nan Fu

AU - Lai, Hsin Chih

AU - Liu, Kou Chen

N1 - Funding Information: This research is supported and funded by the Taiwan NSC 10-0232-5B18-2006 and Taiwan NRPB 10-0IDP-1008-2 .

PY - 2014/7/31

Y1 - 2014/7/31

N2 - This study aims to improve the signal sensitivity of a portable surface plasmon resonance (SPR) sensor system. An organic light emitting diode (OLED) was integrated with a brightness enhancement film (BEF) and a giant birefringent optical (GBO) film as a light source to construct the SPR based on an OLED-BEF-GBO film. A method for calculating the SPR signal by summing the differences in optical intensity at two different wavelengths was used to minimize the effect of the noise error that particularly occurs in a portable SPR device. The experimental results indicated that the limit of detection (LOD) of the SPR using an Au sensing layer has an effective refractive index change of 7.8 × 10-6 RIU. Furthermore, for the SPR using Au/Ag sensing metal layers, an LOD of 3.2 × 10-6 RIU was achieved due to the improved sensitivity and resolution value compared with the use of an Au sensing layer. The use of the SPR device in a bio-affinity assay to test the interaction between goat anti-mouse immunoglobulin G (IgG) and mouse IgG protein achieved a LOD of approximately 40.6 pg/mL.

AB - This study aims to improve the signal sensitivity of a portable surface plasmon resonance (SPR) sensor system. An organic light emitting diode (OLED) was integrated with a brightness enhancement film (BEF) and a giant birefringent optical (GBO) film as a light source to construct the SPR based on an OLED-BEF-GBO film. A method for calculating the SPR signal by summing the differences in optical intensity at two different wavelengths was used to minimize the effect of the noise error that particularly occurs in a portable SPR device. The experimental results indicated that the limit of detection (LOD) of the SPR using an Au sensing layer has an effective refractive index change of 7.8 × 10-6 RIU. Furthermore, for the SPR using Au/Ag sensing metal layers, an LOD of 3.2 × 10-6 RIU was achieved due to the improved sensitivity and resolution value compared with the use of an Au sensing layer. The use of the SPR device in a bio-affinity assay to test the interaction between goat anti-mouse immunoglobulin G (IgG) and mouse IgG protein achieved a LOD of approximately 40.6 pg/mL.

KW - Biosensor

KW - Brightness enhancement film (BEF)

KW - GBO film

KW - Organic light emitting diode (OLED)

KW - Surface plasmon resonance (SPR)

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JO - Sensors and Actuators, B: Chemical

JF - Sensors and Actuators, B: Chemical

ER -

Application of an OLED integrated with BEF and giant birefringent optical (GBO) film in a SPR biosensor

Abstract

Keywords

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