Apolipoprotein E, angiotensin-converting enzyme and kallikrein gene polymorphisms and the risk of Alzheimer's disease and vascular dementia

H. K. Wang, H. C. Fung, W. C. Hsu, Y. R. Wu, J. C. Lin, L. S. Ro, K. H. Chang, F. J. Hwu, Y. Hsu, S. Y. Huang, G. J. Lee-Chen, C. M. Chen

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Abstract

Lipoproteins and vascular factors may play roles in the development of Alzheimer's disease (AD) and/or vascular dementia (VaD). In this study, odd ratios (ORs) and 95% confidence intervals (CIs) for apolipoprotein E (APOE), angiotensin-converting enzyme (ACE), and kallikrein (KLK1) polymorphisms were computed to test their association with the disease by a case-control study. The risk of AD was significantly increased for individuals with APOE ε4 allele (OR = 3.73, 95% CI = 2.38-5.98). The risk of AD was also significant for people with ACE DD genotype, D allele, or T-D haplotype [OR (95% CI) = 4.29 (1.96-10.23), 1.90 (1.35-2.70), or 2.91 (1.71-5.10), respectively]. The above association between ACE-VaD was also strong (p = 0.0012, 0.0050, 0.0007, respectively). Reporter constructs containing the -240 A or T allele displayed similar transcriptional activity in both HEK-293 and IMR-32 cells. Thus, another putative pathogenic marker that is linked with the Alu D allele might affect the risk of AD and VaD in Taiwan.

Original languageEnglish
Pages (from-to)1499-1509
Number of pages11
JournalJournal of Neural Transmission
Volume113
Issue number10
DOIs
Publication statusPublished - 2006 Oct 1

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Keywords

  • Alzheimer's disease
  • Angiotensin- converting enzyme
  • Apolipoprotein E
  • Kallikrein
  • Polymorphism and disease association
  • Vascular dementia

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Wang, H. K., Fung, H. C., Hsu, W. C., Wu, Y. R., Lin, J. C., Ro, L. S., Chang, K. H., Hwu, F. J., Hsu, Y., Huang, S. Y., Lee-Chen, G. J., & Chen, C. M. (2006). Apolipoprotein E, angiotensin-converting enzyme and kallikrein gene polymorphisms and the risk of Alzheimer's disease and vascular dementia. Journal of Neural Transmission, 113(10), 1499-1509. https://doi.org/10.1007/s00702-005-0424-z