Antrodia camphorata extract induces replicative senescence in superficial TCC, and inhibits the absolute migration capability in invasive bladder carcinoma cells

Chiung Chi Peng, Kuan Chou Chen, Robert Y. Peng, Charng Cherng Chyau, Ching Hua Su, Hsiu Mei Hsieh-Li

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

The Antrodia camphorata crude extract (ACCE), an extract obtained from a precious traditional Chinese folkloric herbal medicine Zhan-Ku (a camphor tree mushroom) since the 18th century, has showed rather significant inhibitory effects on the growth and proliferation of the transitional cell carcinomas (TCC) cell lines RT4, TSGH-8301, and T24. On treatment with ACCE at 100 μg/mL, the p53-independent overexpression of p21 with simultaneous down alteration of pRb was observed in RT4, which was thus speculative of proceeding through a mechanism of replicative senescence. On the contrary treatment with ACCE, at 50 μg/mL, resulting in simultaneous down-regulations of Cdc2 and Cyclin B1, with suppression of the absolute migrating capability of the two cell lines TSGH-8301 and T24, and eventually the cell deaths. We conclude that ACCE can be rather effective and beneficial in suppression of both the superficial cancer cell line RT4 and the metastatic cell lines (TSGH-8301 and T24) through different mechanisms.

Original languageEnglish
Pages (from-to)93-103
Number of pages11
JournalJournal of Ethnopharmacology
Volume109
Issue number1
DOIs
Publication statusPublished - 2007 Jan 3

Keywords

  • Antrodia camphorata
  • Rb
  • Replicative senescence
  • TCC
  • p21
  • p53

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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