Antioxidant and anti-inflammatory properties of cancer preventive peptide lunasin in RAW 264.7 macrophages

Blanca Hernández-Ledesma, Chia Chien Hsieh, Ben O. de Lumen

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

Oxidative stress and inflammation are two of the most critical factors implicated in carcinogenesis and other degenerative disorders. We have investigated how lunasin, a known anti-cancer seed peptide, affect these factors. This peptide inhibits linoleic acid oxidation and acts as 2,2′-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) radical scavenger. Furthermore, using LPS-stimulated RAW 264.7 macrophages, we have demonstrated that lunasin reduces, in a significant dose-dependent manner, the production of reactive oxygen species (ROS) by LPS-induced macrophages. Lunasin also inhibits the release of pro-inflammatory cytokines (tumor necrosis factor-α [TNF-α] and interleukine-6 [IL-6]). On the basis of these potent antioxidant and anti-inflammatory properties, we propose lunasin not only as a cancer preventive and therapeutic agent but also as an agent against other inflammatory-related disorders.

Original languageEnglish
Pages (from-to)803-808
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume390
Issue number3
DOIs
Publication statusPublished - 2009 Dec 18

Fingerprint

Macrophages
Anti-Inflammatory Agents
Antioxidants
Peptides
Oxidative stress
Sulfonic Acids
Linoleic Acid
Seed
Reactive Oxygen Species
Neoplasms
Seeds
Carcinogenesis
Oxidative Stress
Tumor Necrosis Factor-alpha
Salts
Cytokines
Inflammation
Oxidation
Therapeutics
2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid

Keywords

  • Anti-inflammatory activity
  • Antioxidant activity
  • Lunasin
  • Macrophages

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Antioxidant and anti-inflammatory properties of cancer preventive peptide lunasin in RAW 264.7 macrophages. / Hernández-Ledesma, Blanca; Hsieh, Chia Chien; de Lumen, Ben O.

In: Biochemical and Biophysical Research Communications, Vol. 390, No. 3, 18.12.2009, p. 803-808.

Research output: Contribution to journalArticle

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