Analyze fluorescent characteristic of cancer cell using hyperspectroscopic imaging system (HIS)

Yao Fang Hsieh, Chih Hsien Chen, Ou Yang Mang, Jeng Ren Duann, Jin Chern Chiou, Shun De Wu, Yong Jiun Lin, Ming Hsui Tsai, Nai Wen Chang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Currently, the cancer was examined by diagnosing the pathological changes of tumor. If the examination of cancer can diagnose the tumor before the cell occur the pathological changes, the cure rate of cancer will increase. This research develops a human-machine interface for hyper-spectral microscope. The hyper-spectral microscope can scan the specific area of cell and records the data of spectrum and intensity. These data is helpful to diagnose tumor. This study finds the hyper-spectral imaging have two higher intensity points at 550nm and 700nm, and one lower point at 640nm between the two higher points. For analyzing the hyper-spectral imaging, the intensity at the 550nm peak divided by the intensity at 700nm peak. Finally, we determine the accuracy of detection by Gaussian distribution. The accuracy of detecting normal cells achieves 89%, and the accuracy of cancer cells achieves 81%.

Original languageEnglish
Title of host publicationThree-Dimensional and Multidimensional Microscopy
Subtitle of host publicationImage Acquisition and Processing XIX
DOIs
Publication statusPublished - 2012 Apr 16
Externally publishedYes
EventThree-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XIX - San Francisco, CA, United States
Duration: 2012 Jan 242012 Jan 26

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8227
ISSN (Print)1605-7422

Conference

ConferenceThree-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XIX
CountryUnited States
CitySan Francisco, CA
Period12/1/2412/1/26

Keywords

  • cancer
  • chacteristic
  • diagnosis
  • fluorescence
  • hyperspectral
  • microscope

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Hsieh, Y. F., Chen, C. H., Mang, O. Y., Duann, J. R., Chiou, J. C., Wu, S. D., Lin, Y. J., Tsai, M. H., & Chang, N. W. (2012). Analyze fluorescent characteristic of cancer cell using hyperspectroscopic imaging system (HIS). In Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XIX [822712] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8227). https://doi.org/10.1117/12.907930