Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese

E. K. Tan; C. S. Lu; R. Peng; Y. Y. Teo; Y. H. Wu-Chou; R. S. Chen; Y. H. Weng; C. M. Chen; H. C. Fung; L. C. Tan; Z. J. Zhang; X. K. An; G. J. Lee-Chen; M. C. Lee; S. Fook-Chong; J. M. Burgunder; R. M. Wu; Y. R. Wu

doi:10.1016/j.neurobiolaging.2008.11.008

Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese

E. K. Tan, C. S. Lu, R. Peng, Y. Y. Teo, Y. H. Wu-Chou, R. S. Chen, Y. H. Weng, C. M. Chen, H. C. Fung, L. C. Tan, Z. J. Zhang, X. K. An, G. J. Lee-Chen, M. C. Lee, S. Fook-Chong, J. M. Burgunder, R. M. Wu, Y. R. Wu^*

^*Corresponding author for this work

Department of Life Science

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y variant with Parkinson's disease (PD) among Caucasian populations has been debated. We conducted a large-scale analysis to investigate the age-of-onset effect of the UCHL1 variant in PD among ethnic Chinese. Individual data sets from 5 centers comprising a total of 4088 study subjects were analyzed. In the univariate analysis, only data from 1 center showed a trend towards a protective effect among young subjects. However, in the combined analysis, no significant association between the UCHL1 variant and PD was detected (A allele frequency 0.531 vs. 0.528, p=0.87, OR 1.01, 95% CI 0.92-1.1). Among subjects less than 60 years old, the OR is 0.99 (95% CI 0.84-1.16, p=0.88). A multivariate logistic regression analysis showed that family history, UCHL1 variant and the interaction of UCHL1 variant and age at onset (p=0.816) were not significantly associated with PD.

Original language	English
Pages (from-to)	2194-2196
Number of pages	3
Journal	Neurobiology of Aging
Volume	31
Issue number	12
DOIs	https://doi.org/10.1016/j.neurobiolaging.2008.11.008
Publication status	Published - 2010 Dec

Keywords

Parkinson's disease
Polymorphism
UCHL1

ASJC Scopus subject areas

Clinical Neurology
Geriatrics and Gerontology
Ageing
General Neuroscience
Developmental Biology

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10.1016/j.neurobiolaging.2008.11.008

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Tan, E. K., Lu, C. S., Peng, R., Teo, Y. Y., Wu-Chou, Y. H., Chen, R. S., Weng, Y. H., Chen, C. M., Fung, H. C., Tan, L. C., Zhang, Z. J., An, X. K., Lee-Chen, G. J., Lee, M. C., Fook-Chong, S., Burgunder, J. M., Wu, R. M., & Wu, Y. R. (2010). Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese. Neurobiology of Aging, 31(12), 2194-2196. https://doi.org/10.1016/j.neurobiolaging.2008.11.008

Tan, EK, Lu, CS, Peng, R, Teo, YY, Wu-Chou, YH, Chen, RS, Weng, YH, Chen, CM, Fung, HC, Tan, LC, Zhang, ZJ, An, XK, Lee-Chen, GJ, Lee, MC, Fook-Chong, S, Burgunder, JM, Wu, RM & Wu, YR 2010, 'Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese', Neurobiology of Aging, vol. 31, no. 12, pp. 2194-2196. https://doi.org/10.1016/j.neurobiolaging.2008.11.008

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title = "Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese",

abstract = "The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y variant with Parkinson's disease (PD) among Caucasian populations has been debated. We conducted a large-scale analysis to investigate the age-of-onset effect of the UCHL1 variant in PD among ethnic Chinese. Individual data sets from 5 centers comprising a total of 4088 study subjects were analyzed. In the univariate analysis, only data from 1 center showed a trend towards a protective effect among young subjects. However, in the combined analysis, no significant association between the UCHL1 variant and PD was detected (A allele frequency 0.531 vs. 0.528, p=0.87, OR 1.01, 95% CI 0.92-1.1). Among subjects less than 60 years old, the OR is 0.99 (95% CI 0.84-1.16, p=0.88). A multivariate logistic regression analysis showed that family history, UCHL1 variant and the interaction of UCHL1 variant and age at onset (p=0.816) were not significantly associated with PD.",

keywords = "Parkinson's disease, Polymorphism, UCHL1",

author = "Tan, {E. K.} and Lu, {C. S.} and R. Peng and Teo, {Y. Y.} and Wu-Chou, {Y. H.} and Chen, {R. S.} and Weng, {Y. H.} and Chen, {C. M.} and Fung, {H. C.} and Tan, {L. C.} and Zhang, {Z. J.} and An, {X. K.} and Lee-Chen, {G. J.} and Lee, {M. C.} and S. Fook-Chong and Burgunder, {J. M.} and Wu, {R. M.} and Wu, {Y. R.}",

note = "Funding Information: We thank the support from the National Medical Research Council, Biomedical Research Council, Duke-NUS Graduate Medical School, Singapore Millennium Foundation, SingHealth, West China Hospital, Sichuan University, Chengdu, China, Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Taipei, Taiwan, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. ",

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doi = "10.1016/j.neurobiolaging.2008.11.008",

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T1 - Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese

AU - Tan, E. K.

AU - Lu, C. S.

AU - Peng, R.

AU - Teo, Y. Y.

AU - Wu-Chou, Y. H.

AU - Chen, R. S.

AU - Weng, Y. H.

AU - Chen, C. M.

AU - Fung, H. C.

AU - Tan, L. C.

AU - Zhang, Z. J.

AU - An, X. K.

AU - Lee-Chen, G. J.

AU - Lee, M. C.

AU - Fook-Chong, S.

AU - Burgunder, J. M.

AU - Wu, R. M.

AU - Wu, Y. R.

N1 - Funding Information: We thank the support from the National Medical Research Council, Biomedical Research Council, Duke-NUS Graduate Medical School, Singapore Millennium Foundation, SingHealth, West China Hospital, Sichuan University, Chengdu, China, Chang Gung Memorial Hospital and College of Medicine, Chang Gung University, Taipei, Taiwan, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.

PY - 2010/12

Y1 - 2010/12

N2 - The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y variant with Parkinson's disease (PD) among Caucasian populations has been debated. We conducted a large-scale analysis to investigate the age-of-onset effect of the UCHL1 variant in PD among ethnic Chinese. Individual data sets from 5 centers comprising a total of 4088 study subjects were analyzed. In the univariate analysis, only data from 1 center showed a trend towards a protective effect among young subjects. However, in the combined analysis, no significant association between the UCHL1 variant and PD was detected (A allele frequency 0.531 vs. 0.528, p=0.87, OR 1.01, 95% CI 0.92-1.1). Among subjects less than 60 years old, the OR is 0.99 (95% CI 0.84-1.16, p=0.88). A multivariate logistic regression analysis showed that family history, UCHL1 variant and the interaction of UCHL1 variant and age at onset (p=0.816) were not significantly associated with PD.

AB - The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y variant with Parkinson's disease (PD) among Caucasian populations has been debated. We conducted a large-scale analysis to investigate the age-of-onset effect of the UCHL1 variant in PD among ethnic Chinese. Individual data sets from 5 centers comprising a total of 4088 study subjects were analyzed. In the univariate analysis, only data from 1 center showed a trend towards a protective effect among young subjects. However, in the combined analysis, no significant association between the UCHL1 variant and PD was detected (A allele frequency 0.531 vs. 0.528, p=0.87, OR 1.01, 95% CI 0.92-1.1). Among subjects less than 60 years old, the OR is 0.99 (95% CI 0.84-1.16, p=0.88). A multivariate logistic regression analysis showed that family history, UCHL1 variant and the interaction of UCHL1 variant and age at onset (p=0.816) were not significantly associated with PD.

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KW - Polymorphism

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Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese

Abstract

Keywords

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