Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese

E. K. Tan, C. S. Lu, R. Peng, Y. Y. Teo, Y. H. Wu-Chou, R. S. Chen, Y. H. Weng, C. M. Chen, H. C. Fung, L. C. Tan, Z. J. Zhang, X. K. An, G. J. Lee-Chen, M. C. Lee, S. Fook-Chong, J. M. Burgunder, R. M. Wu, Y. R. Wu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y variant with Parkinson's disease (PD) among Caucasian populations has been debated. We conducted a large-scale analysis to investigate the age-of-onset effect of the UCHL1 variant in PD among ethnic Chinese. Individual data sets from 5 centers comprising a total of 4088 study subjects were analyzed. In the univariate analysis, only data from 1 center showed a trend towards a protective effect among young subjects. However, in the combined analysis, no significant association between the UCHL1 variant and PD was detected (A allele frequency 0.531 vs. 0.528, p=0.87, OR 1.01, 95% CI 0.92-1.1). Among subjects less than 60 years old, the OR is 0.99 (95% CI 0.84-1.16, p=0.88). A multivariate logistic regression analysis showed that family history, UCHL1 variant and the interaction of UCHL1 variant and age at onset (p=0.816) were not significantly associated with PD.

Original languageEnglish
Pages (from-to)2194-2196
Number of pages3
JournalNeurobiology of Aging
Issue number12
Publication statusPublished - 2010 Dec


  • Parkinson's disease
  • Polymorphism
  • UCHL1

ASJC Scopus subject areas

  • General Neuroscience
  • Ageing
  • Developmental Biology
  • Clinical Neurology
  • Geriatrics and Gerontology


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