Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese

E. K. Tan, C. S. Lu, R. Peng, Y. Y. Teo, Y. H. Wu-Chou, R. S. Chen, Y. H. Weng, C. M. Chen, H. C. Fung, L. C. Tan, Z. J. Zhang, X. K. An, G. J. Lee-Chen, M. C. Lee, S. Fook-Chong, J. M. Burgunder, R. M. Wu, Y. R. Wu

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Abstract

The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y variant with Parkinson's disease (PD) among Caucasian populations has been debated. We conducted a large-scale analysis to investigate the age-of-onset effect of the UCHL1 variant in PD among ethnic Chinese. Individual data sets from 5 centers comprising a total of 4088 study subjects were analyzed. In the univariate analysis, only data from 1 center showed a trend towards a protective effect among young subjects. However, in the combined analysis, no significant association between the UCHL1 variant and PD was detected (A allele frequency 0.531 vs. 0.528, p=0.87, OR 1.01, 95% CI 0.92-1.1). Among subjects less than 60 years old, the OR is 0.99 (95% CI 0.84-1.16, p=0.88). A multivariate logistic regression analysis showed that family history, UCHL1 variant and the interaction of UCHL1 variant and age at onset (p=0.816) were not significantly associated with PD.

Original languageEnglish
Pages (from-to)2194-2196
Number of pages3
JournalNeurobiology of Aging
Volume31
Issue number12
DOIs
Publication statusPublished - 2010 Dec 1

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Keywords

  • Parkinson's disease
  • Polymorphism
  • UCHL1

ASJC Scopus subject areas

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Tan, E. K., Lu, C. S., Peng, R., Teo, Y. Y., Wu-Chou, Y. H., Chen, R. S., Weng, Y. H., Chen, C. M., Fung, H. C., Tan, L. C., Zhang, Z. J., An, X. K., Lee-Chen, G. J., Lee, M. C., Fook-Chong, S., Burgunder, J. M., Wu, R. M., & Wu, Y. R. (2010). Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese. Neurobiology of Aging, 31(12), 2194-2196. https://doi.org/10.1016/j.neurobiolaging.2008.11.008