Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese

E. K. Tan, C. S. Lu, R. Peng, Y. Y. Teo, Y. H. Wu-Chou, R. S. Chen, Y. H. Weng, C. M. Chen, H. C. Fung, L. C. Tan, Z. J. Zhang, X. K. An, G. J. Lee-Chen, M. C. Lee, S. Fook-Chong, J. M. Burgunder, R. M. Wu, Y. R. Wu

Research output: Contribution to journalArticle

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Abstract

The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y variant with Parkinson's disease (PD) among Caucasian populations has been debated. We conducted a large-scale analysis to investigate the age-of-onset effect of the UCHL1 variant in PD among ethnic Chinese. Individual data sets from 5 centers comprising a total of 4088 study subjects were analyzed. In the univariate analysis, only data from 1 center showed a trend towards a protective effect among young subjects. However, in the combined analysis, no significant association between the UCHL1 variant and PD was detected (A allele frequency 0.531 vs. 0.528, p=0.87, OR 1.01, 95% CI 0.92-1.1). Among subjects less than 60 years old, the OR is 0.99 (95% CI 0.84-1.16, p=0.88). A multivariate logistic regression analysis showed that family history, UCHL1 variant and the interaction of UCHL1 variant and age at onset (p=0.816) were not significantly associated with PD.

Original languageEnglish
Pages (from-to)2194-2196
Number of pages3
JournalNeurobiology of Aging
Volume31
Issue number12
DOIs
Publication statusPublished - 2010 Dec 1

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Ubiquitin Thiolesterase
Parkinson Disease
Age of Onset
Gene Frequency
Logistic Models
Regression Analysis
Population

Keywords

  • Parkinson's disease
  • Polymorphism
  • UCHL1

ASJC Scopus subject areas

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Tan, E. K., Lu, C. S., Peng, R., Teo, Y. Y., Wu-Chou, Y. H., Chen, R. S., ... Wu, Y. R. (2010). Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese. Neurobiology of Aging, 31(12), 2194-2196. https://doi.org/10.1016/j.neurobiolaging.2008.11.008

Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese. / Tan, E. K.; Lu, C. S.; Peng, R.; Teo, Y. Y.; Wu-Chou, Y. H.; Chen, R. S.; Weng, Y. H.; Chen, C. M.; Fung, H. C.; Tan, L. C.; Zhang, Z. J.; An, X. K.; Lee-Chen, G. J.; Lee, M. C.; Fook-Chong, S.; Burgunder, J. M.; Wu, R. M.; Wu, Y. R.

In: Neurobiology of Aging, Vol. 31, No. 12, 01.12.2010, p. 2194-2196.

Research output: Contribution to journalArticle

Tan, EK, Lu, CS, Peng, R, Teo, YY, Wu-Chou, YH, Chen, RS, Weng, YH, Chen, CM, Fung, HC, Tan, LC, Zhang, ZJ, An, XK, Lee-Chen, GJ, Lee, MC, Fook-Chong, S, Burgunder, JM, Wu, RM & Wu, YR 2010, 'Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese', Neurobiology of Aging, vol. 31, no. 12, pp. 2194-2196. https://doi.org/10.1016/j.neurobiolaging.2008.11.008
Tan, E. K. ; Lu, C. S. ; Peng, R. ; Teo, Y. Y. ; Wu-Chou, Y. H. ; Chen, R. S. ; Weng, Y. H. ; Chen, C. M. ; Fung, H. C. ; Tan, L. C. ; Zhang, Z. J. ; An, X. K. ; Lee-Chen, G. J. ; Lee, M. C. ; Fook-Chong, S. ; Burgunder, J. M. ; Wu, R. M. ; Wu, Y. R. / Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese. In: Neurobiology of Aging. 2010 ; Vol. 31, No. 12. pp. 2194-2196.
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