Analysis of magnetic nanoparticles using second harmonic responses

Saburo Tanaka; Toshifumi Suzuki; Kazuya Kobayashi; Shu Hsien Liao; Herng Er Horng; Hong Chang Yang

doi:10.1016/j.jmmm.2016.12.067

Analysis of magnetic nanoparticles using second harmonic responses

Saburo Tanaka, Toshifumi Suzuki, Kazuya Kobayashi, Shu Hsien Liao, Herng Er Horng, Hong Chang Yang

Graduate Institute of Electro-Optical Science And Technology

Research output: Contribution to journal › Article

2 Citations (Scopus)

Abstract

Magnetic particle imaging (MPI) is a new medical imaging technology with a number of potential applications. It is based on utilizing the non-linear magnetization response for magnetic nanoparticles (MNPs). We have proposed a method to improve the detection sensitivity for the magnetization of MNPs, and their imaging technique, based on the detection of a second harmonic of the response using a high Tc SQUID. The advantage of using the second harmonic is that the response can be measured even with small amplitudes. In this paper, superparamagnetic MNPs with different diameters and different compositions of materials were analyzed by this method. In the MNPs, Resovist was found to be almost one order of magnitude larger than that of the other MNPs tested. The magnetic moments of the MNPs were estimated by fitting with the Langevin function to obtain the magnetic moments m of Resovist of 3.62×10⁻¹⁸ [J/T]. The magnetic moment m of Resovist was 7.4 times larger than the other MNPs.

Original language	English
Pages (from-to)	189-191
Number of pages	3
Journal	Journal of Magnetism and Magnetic Materials
Volume	440
DOIs	https://doi.org/10.1016/j.jmmm.2016.12.067
Publication status	Published - 2017 Oct 15

Keywords

Detection
Harmonic
Magnetic sensor
Nanoparticle
SQUID

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics

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title = "Analysis of magnetic nanoparticles using second harmonic responses",

abstract = "Magnetic particle imaging (MPI) is a new medical imaging technology with a number of potential applications. It is based on utilizing the non-linear magnetization response for magnetic nanoparticles (MNPs). We have proposed a method to improve the detection sensitivity for the magnetization of MNPs, and their imaging technique, based on the detection of a second harmonic of the response using a high Tc SQUID. The advantage of using the second harmonic is that the response can be measured even with small amplitudes. In this paper, superparamagnetic MNPs with different diameters and different compositions of materials were analyzed by this method. In the MNPs, Resovist was found to be almost one order of magnitude larger than that of the other MNPs tested. The magnetic moments of the MNPs were estimated by fitting with the Langevin function to obtain the magnetic moments m of Resovist of 3.62×10−18 [J/T]. The magnetic moment m of Resovist was 7.4 times larger than the other MNPs.",

keywords = "Detection, Harmonic, Magnetic sensor, Nanoparticle, SQUID",

author = "Saburo Tanaka and Toshifumi Suzuki and Kazuya Kobayashi and Liao, {Shu Hsien} and Horng, {Herng Er} and Yang, {Hong Chang}",

year = "2017",

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day = "15",

doi = "10.1016/j.jmmm.2016.12.067",

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T1 - Analysis of magnetic nanoparticles using second harmonic responses

AU - Tanaka, Saburo

AU - Suzuki, Toshifumi

AU - Kobayashi, Kazuya

AU - Liao, Shu Hsien

AU - Horng, Herng Er

AU - Yang, Hong Chang

PY - 2017/10/15

Y1 - 2017/10/15

N2 - Magnetic particle imaging (MPI) is a new medical imaging technology with a number of potential applications. It is based on utilizing the non-linear magnetization response for magnetic nanoparticles (MNPs). We have proposed a method to improve the detection sensitivity for the magnetization of MNPs, and their imaging technique, based on the detection of a second harmonic of the response using a high Tc SQUID. The advantage of using the second harmonic is that the response can be measured even with small amplitudes. In this paper, superparamagnetic MNPs with different diameters and different compositions of materials were analyzed by this method. In the MNPs, Resovist was found to be almost one order of magnitude larger than that of the other MNPs tested. The magnetic moments of the MNPs were estimated by fitting with the Langevin function to obtain the magnetic moments m of Resovist of 3.62×10−18 [J/T]. The magnetic moment m of Resovist was 7.4 times larger than the other MNPs.

AB - Magnetic particle imaging (MPI) is a new medical imaging technology with a number of potential applications. It is based on utilizing the non-linear magnetization response for magnetic nanoparticles (MNPs). We have proposed a method to improve the detection sensitivity for the magnetization of MNPs, and their imaging technique, based on the detection of a second harmonic of the response using a high Tc SQUID. The advantage of using the second harmonic is that the response can be measured even with small amplitudes. In this paper, superparamagnetic MNPs with different diameters and different compositions of materials were analyzed by this method. In the MNPs, Resovist was found to be almost one order of magnitude larger than that of the other MNPs tested. The magnetic moments of the MNPs were estimated by fitting with the Langevin function to obtain the magnetic moments m of Resovist of 3.62×10−18 [J/T]. The magnetic moment m of Resovist was 7.4 times larger than the other MNPs.

KW - Detection

KW - Harmonic

KW - Magnetic sensor

KW - Nanoparticle

KW - SQUID

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