Abstract
Common genetic variants that increase the risk for Parkinson's disease may differentiate patient subgroups and influence future individualized therapeutic strategies. Herein we show evidence for leucine-rich repeat kinase 2 (LRRK2) c.4883G>C (R1628P) as a risk factor in ethnic Chinese populations. A study of 1,986 individuals from 3 independent centers in Taiwan and Singapore demonstrates that Lrrk2 R1628P increases risk for Parkinson's disease (odds ratio, 1.84; 95% confidence interval, 1.20-2.83; p = 0.006). Haplotype analysis suggests an ancestral founder for carriers approximately 2,500 years ago. These findings support the importance of LKRK2 variants in sporadic Parkinson's disease.
Original language | English |
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Pages (from-to) | 88-92 |
Number of pages | 5 |
Journal | Annals of Neurology |
Volume | 64 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2008 Jul |
ASJC Scopus subject areas
- Neurology
- Clinical Neurology