Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease

Owen A. Ross, Yih Ru Wu*, Mei Ching Lee, Manabu Funayama, Meng Ling Chen, Alexandra I. Soto, Ignacio F. Mata, Guey Jen Lee-Chen, Mei Chen Chiung, Michelle Tang, Yi Zhao, Nobutaka Hattori, Matthew J. Farrer, Eng King Tan, Ruey Meei Wu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

167 Citations (Scopus)


Common genetic variants that increase the risk for Parkinson's disease may differentiate patient subgroups and influence future individualized therapeutic strategies. Herein we show evidence for leucine-rich repeat kinase 2 (LRRK2) c.4883G>C (R1628P) as a risk factor in ethnic Chinese populations. A study of 1,986 individuals from 3 independent centers in Taiwan and Singapore demonstrates that Lrrk2 R1628P increases risk for Parkinson's disease (odds ratio, 1.84; 95% confidence interval, 1.20-2.83; p = 0.006). Haplotype analysis suggests an ancestral founder for carriers approximately 2,500 years ago. These findings support the importance of LKRK2 variants in sporadic Parkinson's disease.

Original languageEnglish
Pages (from-to)88-92
Number of pages5
JournalAnnals of Neurology
Issue number1
Publication statusPublished - 2008 Jul

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


Dive into the research topics of 'Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease'. Together they form a unique fingerprint.

Cite this