Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease

Owen A. Ross, Yih Ru Wu, Mei Ching Lee, Manabu Funayama, Meng Ling Chen, Alexandra I. Soto, Ignacio F. Mata, Guey Jen Lee-Chen, Mei Chen Chiung, Michelle Tang, Yi Zhao, Nobutaka Hattori, Matthew J. Farrer, Eng King Tan, Ruey Meei Wu

Research output: Contribution to journalArticle

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Abstract

Common genetic variants that increase the risk for Parkinson's disease may differentiate patient subgroups and influence future individualized therapeutic strategies. Herein we show evidence for leucine-rich repeat kinase 2 (LRRK2) c.4883G>C (R1628P) as a risk factor in ethnic Chinese populations. A study of 1,986 individuals from 3 independent centers in Taiwan and Singapore demonstrates that Lrrk2 R1628P increases risk for Parkinson's disease (odds ratio, 1.84; 95% confidence interval, 1.20-2.83; p = 0.006). Haplotype analysis suggests an ancestral founder for carriers approximately 2,500 years ago. These findings support the importance of LKRK2 variants in sporadic Parkinson's disease.

Original languageEnglish
Pages (from-to)88-92
Number of pages5
JournalAnnals of Neurology
Volume64
Issue number1
DOIs
Publication statusPublished - 2008 Jul 1

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Parkinson Disease
Singapore
Taiwan
Leucine
Haplotypes
Phosphotransferases
Odds Ratio
Confidence Intervals
Population
Therapeutics

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Ross, O. A., Wu, Y. R., Lee, M. C., Funayama, M., Chen, M. L., Soto, A. I., ... Wu, R. M. (2008). Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease. Annals of Neurology, 64(1), 88-92. https://doi.org/10.1002/ana.21405

Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease. / Ross, Owen A.; Wu, Yih Ru; Lee, Mei Ching; Funayama, Manabu; Chen, Meng Ling; Soto, Alexandra I.; Mata, Ignacio F.; Lee-Chen, Guey Jen; Chiung, Mei Chen; Tang, Michelle; Zhao, Yi; Hattori, Nobutaka; Farrer, Matthew J.; Tan, Eng King; Wu, Ruey Meei.

In: Annals of Neurology, Vol. 64, No. 1, 01.07.2008, p. 88-92.

Research output: Contribution to journalArticle

Ross, OA, Wu, YR, Lee, MC, Funayama, M, Chen, ML, Soto, AI, Mata, IF, Lee-Chen, GJ, Chiung, MC, Tang, M, Zhao, Y, Hattori, N, Farrer, MJ, Tan, EK & Wu, RM 2008, 'Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease', Annals of Neurology, vol. 64, no. 1, pp. 88-92. https://doi.org/10.1002/ana.21405
Ross OA, Wu YR, Lee MC, Funayama M, Chen ML, Soto AI et al. Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease. Annals of Neurology. 2008 Jul 1;64(1):88-92. https://doi.org/10.1002/ana.21405
Ross, Owen A. ; Wu, Yih Ru ; Lee, Mei Ching ; Funayama, Manabu ; Chen, Meng Ling ; Soto, Alexandra I. ; Mata, Ignacio F. ; Lee-Chen, Guey Jen ; Chiung, Mei Chen ; Tang, Michelle ; Zhao, Yi ; Hattori, Nobutaka ; Farrer, Matthew J. ; Tan, Eng King ; Wu, Ruey Meei. / Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease. In: Annals of Neurology. 2008 ; Vol. 64, No. 1. pp. 88-92.
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