Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease

Owen A. Ross, Yih Ru Wu, Mei Ching Lee, Manabu Funayama, Meng Ling Chen, Alexandra I. Soto, Ignacio F. Mata, Guey Jen Lee-Chen, Mei Chen Chiung, Michelle Tang, Yi Zhao, Nobutaka Hattori, Matthew J. Farrer, Eng King Tan, Ruey Meei Wu

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Abstract

Common genetic variants that increase the risk for Parkinson's disease may differentiate patient subgroups and influence future individualized therapeutic strategies. Herein we show evidence for leucine-rich repeat kinase 2 (LRRK2) c.4883G>C (R1628P) as a risk factor in ethnic Chinese populations. A study of 1,986 individuals from 3 independent centers in Taiwan and Singapore demonstrates that Lrrk2 R1628P increases risk for Parkinson's disease (odds ratio, 1.84; 95% confidence interval, 1.20-2.83; p = 0.006). Haplotype analysis suggests an ancestral founder for carriers approximately 2,500 years ago. These findings support the importance of LKRK2 variants in sporadic Parkinson's disease.

Original languageEnglish
Pages (from-to)88-92
Number of pages5
JournalAnnals of Neurology
Volume64
Issue number1
DOIs
Publication statusPublished - 2008 Jul 1

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ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Ross, O. A., Wu, Y. R., Lee, M. C., Funayama, M., Chen, M. L., Soto, A. I., Mata, I. F., Lee-Chen, G. J., Chiung, M. C., Tang, M., Zhao, Y., Hattori, N., Farrer, M. J., Tan, E. K., & Wu, R. M. (2008). Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease. Annals of Neurology, 64(1), 88-92. https://doi.org/10.1002/ana.21405