Analysis of highly polar pesticides in foods by LC-MS/MS

Wan Rou Liao, Kuan Lu Wu, Kun Hao Chiang, Chieh En Teng, Sung Fang Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Highly polar pesticides (HPP) are a group of pesticides that are characterize as low Log Kow. Many high-throughput multi-residue analysis methods based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the simultaneous determination of such polar pesticides have been proposed. In this article, we summarize the various sample preparation methods including quick polar pesticides (QuPPe), dispersive solid phase extraction (dSPE), solid phase extraction (SPE) and QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe), especially for QuPPe, which are mainly used for the determination of HPP in foods. In addition, we summarize LC-based separation methodologies that are currently used for the analysis of HPP in foods, including reversed-phase chromatography (RPC), hydrophilic interaction liquid chromatography (HILIC), ion chromatography (IC) and mixed-mode chromatography (MMC). Finally, the current mass spectrometry-based methodologies for the analysis of HPP are summarized with a specific focus on MS configurations and acquisition modes.

Original languageEnglish
Pages (from-to)538-548
Number of pages11
JournalJournal of Food and Drug Analysis
Issue number4
Publication statusPublished - 2022


  • Highly polar pesticides (HPP)
  • QuPPe

ASJC Scopus subject areas

  • Food Science
  • Pharmacology


Dive into the research topics of 'Analysis of highly polar pesticides in foods by LC-MS/MS'. Together they form a unique fingerprint.

Cite this