Analyses of interaction effect between apolipoprotein E polymorphism and alcohol use as well as cholesterol concentrations on spontaneous deep intracerebral hemorrhage in the Taiwan population

Yi Chun Chen, Guey-Jen Lee, Yih Ru Wu, Fen Ju Hu, Hsiu Chuan Wu, Hung Chou Kuo, Chun Che Chu, Shan Jin Ryu, Sien Tsong Chen, Chiung Mei Chen

Research output: Contribution to journalArticle

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Abstract

Background: To determine the interaction effect between APOE polymorphism and lipid concentrations and alcohol use on spontaneous deep intracerebral hemorrhage (SDICH) risks. Methods: We enrolled 217 SDICH patients and 280 controls. Anthropometrics, personal history, and concentrations of total cholesterol (TC), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDL-c), and triglyceride were collected. Genotyping was determined by PCR-based restriction and electrophoresis assay. Associations were tested adjusting for multiple covariables. Results: Compared with the commonest genotype ε3ε3, ε2ε3 was inversely associated with TC (p = 0.023) and LDL-c concentrations (p = 0.005) in women. No APOE-alcohol interaction effect on lipids concentration was found. However, in men, there was a marginal effect of interaction between alcohol and APOE genotype ε2ε3 vs. ε3ε3 on SDICH risks (p = 0.003), which is independent of TC concentration. In the male non-alcohol group, SDICH proportion was lower in the subjects carrying APOE ε2ε3 (27.6%) than in those with ε3ε3 (41.1%). In contrast, in the male alcohol consumption group, APOE ε2ε3 was associated with a higher SDICH rate (77.8%) compared to ε3ε3 (58.0%). Conclusions: Male subjects carrying genotype ε2ε3 tend to have a higher SDICH risk than those who have ε3ε3 when they have alcohol exposure, but may have more benefit from alcohol abstinence.

Original languageEnglish
Pages (from-to)128-132
Number of pages5
JournalClinica Chimica Acta
Volume408
Issue number1-2
DOIs
Publication statusPublished - 2009 Oct 1

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Cerebral Hemorrhage
Apolipoproteins E
Polymorphism
Taiwan
Cholesterol
Alcohols
Population
Genotype
LDL Cholesterol
Alcohol Abstinence
Lipids
Electrophoresis
Alcohol Drinking
HDL Cholesterol
Assays
Polymerase Chain Reaction

Keywords

  • Alcohol
  • Apolipoprotein E
  • Cholesterol
  • Genetics
  • Intracerebral hemorrhage
  • Polymorphism and disease association

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Analyses of interaction effect between apolipoprotein E polymorphism and alcohol use as well as cholesterol concentrations on spontaneous deep intracerebral hemorrhage in the Taiwan population. / Chen, Yi Chun; Lee, Guey-Jen; Wu, Yih Ru; Hu, Fen Ju; Wu, Hsiu Chuan; Kuo, Hung Chou; Chu, Chun Che; Ryu, Shan Jin; Chen, Sien Tsong; Chen, Chiung Mei.

In: Clinica Chimica Acta, Vol. 408, No. 1-2, 01.10.2009, p. 128-132.

Research output: Contribution to journalArticle

Chen, Yi Chun ; Lee, Guey-Jen ; Wu, Yih Ru ; Hu, Fen Ju ; Wu, Hsiu Chuan ; Kuo, Hung Chou ; Chu, Chun Che ; Ryu, Shan Jin ; Chen, Sien Tsong ; Chen, Chiung Mei. / Analyses of interaction effect between apolipoprotein E polymorphism and alcohol use as well as cholesterol concentrations on spontaneous deep intracerebral hemorrhage in the Taiwan population. In: Clinica Chimica Acta. 2009 ; Vol. 408, No. 1-2. pp. 128-132.
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abstract = "Background: To determine the interaction effect between APOE polymorphism and lipid concentrations and alcohol use on spontaneous deep intracerebral hemorrhage (SDICH) risks. Methods: We enrolled 217 SDICH patients and 280 controls. Anthropometrics, personal history, and concentrations of total cholesterol (TC), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDL-c), and triglyceride were collected. Genotyping was determined by PCR-based restriction and electrophoresis assay. Associations were tested adjusting for multiple covariables. Results: Compared with the commonest genotype ε3ε3, ε2ε3 was inversely associated with TC (p = 0.023) and LDL-c concentrations (p = 0.005) in women. No APOE-alcohol interaction effect on lipids concentration was found. However, in men, there was a marginal effect of interaction between alcohol and APOE genotype ε2ε3 vs. ε3ε3 on SDICH risks (p = 0.003), which is independent of TC concentration. In the male non-alcohol group, SDICH proportion was lower in the subjects carrying APOE ε2ε3 (27.6{\%}) than in those with ε3ε3 (41.1{\%}). In contrast, in the male alcohol consumption group, APOE ε2ε3 was associated with a higher SDICH rate (77.8{\%}) compared to ε3ε3 (58.0{\%}). Conclusions: Male subjects carrying genotype ε2ε3 tend to have a higher SDICH risk than those who have ε3ε3 when they have alcohol exposure, but may have more benefit from alcohol abstinence.",
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T1 - Analyses of interaction effect between apolipoprotein E polymorphism and alcohol use as well as cholesterol concentrations on spontaneous deep intracerebral hemorrhage in the Taiwan population

AU - Chen, Yi Chun

AU - Lee, Guey-Jen

AU - Wu, Yih Ru

AU - Hu, Fen Ju

AU - Wu, Hsiu Chuan

AU - Kuo, Hung Chou

AU - Chu, Chun Che

AU - Ryu, Shan Jin

AU - Chen, Sien Tsong

AU - Chen, Chiung Mei

PY - 2009/10/1

Y1 - 2009/10/1

N2 - Background: To determine the interaction effect between APOE polymorphism and lipid concentrations and alcohol use on spontaneous deep intracerebral hemorrhage (SDICH) risks. Methods: We enrolled 217 SDICH patients and 280 controls. Anthropometrics, personal history, and concentrations of total cholesterol (TC), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDL-c), and triglyceride were collected. Genotyping was determined by PCR-based restriction and electrophoresis assay. Associations were tested adjusting for multiple covariables. Results: Compared with the commonest genotype ε3ε3, ε2ε3 was inversely associated with TC (p = 0.023) and LDL-c concentrations (p = 0.005) in women. No APOE-alcohol interaction effect on lipids concentration was found. However, in men, there was a marginal effect of interaction between alcohol and APOE genotype ε2ε3 vs. ε3ε3 on SDICH risks (p = 0.003), which is independent of TC concentration. In the male non-alcohol group, SDICH proportion was lower in the subjects carrying APOE ε2ε3 (27.6%) than in those with ε3ε3 (41.1%). In contrast, in the male alcohol consumption group, APOE ε2ε3 was associated with a higher SDICH rate (77.8%) compared to ε3ε3 (58.0%). Conclusions: Male subjects carrying genotype ε2ε3 tend to have a higher SDICH risk than those who have ε3ε3 when they have alcohol exposure, but may have more benefit from alcohol abstinence.

AB - Background: To determine the interaction effect between APOE polymorphism and lipid concentrations and alcohol use on spontaneous deep intracerebral hemorrhage (SDICH) risks. Methods: We enrolled 217 SDICH patients and 280 controls. Anthropometrics, personal history, and concentrations of total cholesterol (TC), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDL-c), and triglyceride were collected. Genotyping was determined by PCR-based restriction and electrophoresis assay. Associations were tested adjusting for multiple covariables. Results: Compared with the commonest genotype ε3ε3, ε2ε3 was inversely associated with TC (p = 0.023) and LDL-c concentrations (p = 0.005) in women. No APOE-alcohol interaction effect on lipids concentration was found. However, in men, there was a marginal effect of interaction between alcohol and APOE genotype ε2ε3 vs. ε3ε3 on SDICH risks (p = 0.003), which is independent of TC concentration. In the male non-alcohol group, SDICH proportion was lower in the subjects carrying APOE ε2ε3 (27.6%) than in those with ε3ε3 (41.1%). In contrast, in the male alcohol consumption group, APOE ε2ε3 was associated with a higher SDICH rate (77.8%) compared to ε3ε3 (58.0%). Conclusions: Male subjects carrying genotype ε2ε3 tend to have a higher SDICH risk than those who have ε3ε3 when they have alcohol exposure, but may have more benefit from alcohol abstinence.

KW - Alcohol

KW - Apolipoprotein E

KW - Cholesterol

KW - Genetics

KW - Intracerebral hemorrhage

KW - Polymorphism and disease association

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