Abstract
Background: To determine the interaction effect between APOE polymorphism and lipid concentrations and alcohol use on spontaneous deep intracerebral hemorrhage (SDICH) risks. Methods: We enrolled 217 SDICH patients and 280 controls. Anthropometrics, personal history, and concentrations of total cholesterol (TC), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDL-c), and triglyceride were collected. Genotyping was determined by PCR-based restriction and electrophoresis assay. Associations were tested adjusting for multiple covariables. Results: Compared with the commonest genotype ε3ε3, ε2ε3 was inversely associated with TC (p = 0.023) and LDL-c concentrations (p = 0.005) in women. No APOE-alcohol interaction effect on lipids concentration was found. However, in men, there was a marginal effect of interaction between alcohol and APOE genotype ε2ε3 vs. ε3ε3 on SDICH risks (p = 0.003), which is independent of TC concentration. In the male non-alcohol group, SDICH proportion was lower in the subjects carrying APOE ε2ε3 (27.6%) than in those with ε3ε3 (41.1%). In contrast, in the male alcohol consumption group, APOE ε2ε3 was associated with a higher SDICH rate (77.8%) compared to ε3ε3 (58.0%). Conclusions: Male subjects carrying genotype ε2ε3 tend to have a higher SDICH risk than those who have ε3ε3 when they have alcohol exposure, but may have more benefit from alcohol abstinence.
| Original language | English |
|---|---|
| Pages (from-to) | 128-132 |
| Number of pages | 5 |
| Journal | Clinica Chimica Acta |
| Volume | 408 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 2009 Oct 1 |
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Keywords
- Alcohol
- Apolipoprotein E
- Cholesterol
- Genetics
- Intracerebral hemorrhage
- Polymorphism and disease association
ASJC Scopus subject areas
- Biochemistry
- Clinical Biochemistry
- Biochemistry, medical
Cite this
Analyses of interaction effect between apolipoprotein E polymorphism and alcohol use as well as cholesterol concentrations on spontaneous deep intracerebral hemorrhage in the Taiwan population. / Chen, Yi Chun; Lee, Guey-Jen; Wu, Yih Ru; Hu, Fen Ju; Wu, Hsiu Chuan; Kuo, Hung Chou; Chu, Chun Che; Ryu, Shan Jin; Chen, Sien Tsong; Chen, Chiung Mei.
In: Clinica Chimica Acta, Vol. 408, No. 1-2, 01.10.2009, p. 128-132.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Analyses of interaction effect between apolipoprotein E polymorphism and alcohol use as well as cholesterol concentrations on spontaneous deep intracerebral hemorrhage in the Taiwan population
AU - Chen, Yi Chun
AU - Lee, Guey-Jen
AU - Wu, Yih Ru
AU - Hu, Fen Ju
AU - Wu, Hsiu Chuan
AU - Kuo, Hung Chou
AU - Chu, Chun Che
AU - Ryu, Shan Jin
AU - Chen, Sien Tsong
AU - Chen, Chiung Mei
PY - 2009/10/1
Y1 - 2009/10/1
N2 - Background: To determine the interaction effect between APOE polymorphism and lipid concentrations and alcohol use on spontaneous deep intracerebral hemorrhage (SDICH) risks. Methods: We enrolled 217 SDICH patients and 280 controls. Anthropometrics, personal history, and concentrations of total cholesterol (TC), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDL-c), and triglyceride were collected. Genotyping was determined by PCR-based restriction and electrophoresis assay. Associations were tested adjusting for multiple covariables. Results: Compared with the commonest genotype ε3ε3, ε2ε3 was inversely associated with TC (p = 0.023) and LDL-c concentrations (p = 0.005) in women. No APOE-alcohol interaction effect on lipids concentration was found. However, in men, there was a marginal effect of interaction between alcohol and APOE genotype ε2ε3 vs. ε3ε3 on SDICH risks (p = 0.003), which is independent of TC concentration. In the male non-alcohol group, SDICH proportion was lower in the subjects carrying APOE ε2ε3 (27.6%) than in those with ε3ε3 (41.1%). In contrast, in the male alcohol consumption group, APOE ε2ε3 was associated with a higher SDICH rate (77.8%) compared to ε3ε3 (58.0%). Conclusions: Male subjects carrying genotype ε2ε3 tend to have a higher SDICH risk than those who have ε3ε3 when they have alcohol exposure, but may have more benefit from alcohol abstinence.
AB - Background: To determine the interaction effect between APOE polymorphism and lipid concentrations and alcohol use on spontaneous deep intracerebral hemorrhage (SDICH) risks. Methods: We enrolled 217 SDICH patients and 280 controls. Anthropometrics, personal history, and concentrations of total cholesterol (TC), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDL-c), and triglyceride were collected. Genotyping was determined by PCR-based restriction and electrophoresis assay. Associations were tested adjusting for multiple covariables. Results: Compared with the commonest genotype ε3ε3, ε2ε3 was inversely associated with TC (p = 0.023) and LDL-c concentrations (p = 0.005) in women. No APOE-alcohol interaction effect on lipids concentration was found. However, in men, there was a marginal effect of interaction between alcohol and APOE genotype ε2ε3 vs. ε3ε3 on SDICH risks (p = 0.003), which is independent of TC concentration. In the male non-alcohol group, SDICH proportion was lower in the subjects carrying APOE ε2ε3 (27.6%) than in those with ε3ε3 (41.1%). In contrast, in the male alcohol consumption group, APOE ε2ε3 was associated with a higher SDICH rate (77.8%) compared to ε3ε3 (58.0%). Conclusions: Male subjects carrying genotype ε2ε3 tend to have a higher SDICH risk than those who have ε3ε3 when they have alcohol exposure, but may have more benefit from alcohol abstinence.
KW - Alcohol
KW - Apolipoprotein E
KW - Cholesterol
KW - Genetics
KW - Intracerebral hemorrhage
KW - Polymorphism and disease association
UR - http://www.scopus.com/inward/record.url?scp=69849102282&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=69849102282&partnerID=8YFLogxK
U2 - 10.1016/j.cca.2009.08.004
DO - 10.1016/j.cca.2009.08.004
M3 - Article
C2 - 19686716
AN - SCOPUS:69849102282
VL - 408
SP - 128
EP - 132
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
SN - 0009-8981
IS - 1-2
ER -