An unprecedented route for the synthesis of 3,3′-biindoles by reductive cyclization of 3-[2-Nitro-1-(2-nitrophenyl)ethyl]-1H-indoles mediated by iron/ acetic acid

Chintakunta Ramesh; Veerababurao Kavala; Chun Wei Kuo; B. Rama Raju; Ching-Fa Yao

doi:10.1002/ejoc.201000276

An unprecedented route for the synthesis of 3,3′-biindoles by reductive cyclization of 3-[2-Nitro-1-(2-nitrophenyl)ethyl]-1H-indoles mediated by iron/ acetic acid

Chintakunta Ramesh, Veerababurao Kavala, Chun Wei Kuo, B. Rama Raju, Ching-Fa Yao

Department of Chemistry

Research output: Contribution to journal › Article

24 Citations (Scopus)

Abstract

An unprecedented route for the synthesis of 3,3′-biindoles is developed. Both symmetrical and unsymmetrical 3,3′-biindoles could be generated by this method. Mild conditions, high yields of the products, and environmentally acceptable reagent are the merits of the procedure.

Original language	English
Pages (from-to)	3796-3801
Number of pages	6
Journal	European Journal of Organic Chemistry
Issue number	20
DOIs	https://doi.org/10.1002/ejoc.201000276
Publication status	Published - 2010 Jul 1

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Indoles

Cyclization

indoles

acetic acid

Acetic Acid

reagents

Iron

routes

iron

synthesis

products

Keywords

Cyclization
Iron
Michael addition
Nitroalkenes
Nitrogen heterocycles

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Organic Chemistry

Cite this

Ramesh, C., Kavala, V., Kuo, C. W., Raju, B. R., & Yao, C-F. (2010). An unprecedented route for the synthesis of 3,3′-biindoles by reductive cyclization of 3-[2-Nitro-1-(2-nitrophenyl)ethyl]-1H-indoles mediated by iron/ acetic acid. European Journal of Organic Chemistry, (20), 3796-3801. https://doi.org/10.1002/ejoc.201000276

An unprecedented route for the synthesis of 3,3′-biindoles by reductive cyclization of 3-[2-Nitro-1-(2-nitrophenyl)ethyl]-1H-indoles mediated by iron/ acetic acid. / Ramesh, Chintakunta; Kavala, Veerababurao; Kuo, Chun Wei; Raju, B. Rama; Yao, Ching-Fa.

In: European Journal of Organic Chemistry, No. 20, 01.07.2010, p. 3796-3801.

Research output: Contribution to journal › Article

Ramesh, C, Kavala, V, Kuo, CW, Raju, BR & Yao, C-F 2010, 'An unprecedented route for the synthesis of 3,3′-biindoles by reductive cyclization of 3-[2-Nitro-1-(2-nitrophenyl)ethyl]-1H-indoles mediated by iron/ acetic acid', European Journal of Organic Chemistry, no. 20, pp. 3796-3801. https://doi.org/10.1002/ejoc.201000276

Ramesh C, Kavala V, Kuo CW, Raju BR, Yao C-F. An unprecedented route for the synthesis of 3,3′-biindoles by reductive cyclization of 3-[2-Nitro-1-(2-nitrophenyl)ethyl]-1H-indoles mediated by iron/ acetic acid. European Journal of Organic Chemistry. 2010 Jul 1;(20):3796-3801. https://doi.org/10.1002/ejoc.201000276

Ramesh, Chintakunta ; Kavala, Veerababurao ; Kuo, Chun Wei ; Raju, B. Rama ; Yao, Ching-Fa. / An unprecedented route for the synthesis of 3,3′-biindoles by reductive cyclization of 3-[2-Nitro-1-(2-nitrophenyl)ethyl]-1H-indoles mediated by iron/ acetic acid. In: European Journal of Organic Chemistry. 2010 ; No. 20. pp. 3796-3801.

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10.1002/ejoc.201000276