An implantable multifunctional needle type biosensor with integrated RF capability

Nan-Fu Chiu, Jmin Min Wang, Cheng Wei Liao, Chun Hao Chen, Hsiao Chin Chen, Lung Jieh Yang, Shey Shi Lu, Chii Wann Lin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

8 Citations (Scopus)

Abstract

We report the development of an implantable multifunctional (glucose and cholesterol) needle type biosensor with integrated RF wireless circuitry for continuous in vivo monitoring of metabolites during short term stays in emergency room or intensive care unit. Silicon-based MEMS technologies are used for the fabrication of micro needle sensors. The whole device is covered by a biocompatible Parylene layer with opening structure at the active areas of electrodes. Electropolymerization of active biomolecules and conducting polymer provides in situ nanoscale physical entrapments of various oxidoreductases (Glucose oxidase and cholesterol oxidase) and functions as a viable matrix for the construction of micro amperometric biosensors. Hybrid CMOS fabrication processes are used to accomplish the 433 MHz ASK RF transmitter and receiver (0.18μm CMOS 1P6M process) and the data converter (0.35μm CMOS 2P4M process). We will present and discuss the detail design and the integrated system performance in this paper.

Original languageEnglish
Title of host publicationProceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
Pages1933-1936
Number of pages4
Publication statusPublished - 2005 Dec 1
Event2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005 - Shanghai, China
Duration: 2005 Sep 12005 Sep 4

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume7 VOLS
ISSN (Print)0589-1019

Other

Other2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
CountryChina
CityShanghai
Period05/9/105/9/4

Fingerprint

Cholesterol
Biosensing Techniques
Biosensors
Needles
Cholesterol Oxidase
Emergency rooms
Micro-Electrical-Mechanical Systems
Fabrication
Intensive care units
Glucose Oxidase
Glucose oxidase
Electropolymerization
Conducting polymers
Biomolecules
Emergency Medical Services
Silicon
Metabolites
MEMS
Intensive Care Units
Glucose

Keywords

  • Biosensors
  • Cholesterol
  • Glucose
  • Implantable
  • Multifunction
  • Needle type
  • Parylene
  • Polypyrrole
  • Wireless

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Chiu, N-F., Wang, J. M., Liao, C. W., Chen, C. H., Chen, H. C., Yang, L. J., ... Lin, C. W. (2005). An implantable multifunctional needle type biosensor with integrated RF capability. In Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005 (pp. 1933-1936). [1616830] (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings; Vol. 7 VOLS).

An implantable multifunctional needle type biosensor with integrated RF capability. / Chiu, Nan-Fu; Wang, Jmin Min; Liao, Cheng Wei; Chen, Chun Hao; Chen, Hsiao Chin; Yang, Lung Jieh; Lu, Shey Shi; Lin, Chii Wann.

Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005. 2005. p. 1933-1936 1616830 (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings; Vol. 7 VOLS).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Chiu, N-F, Wang, JM, Liao, CW, Chen, CH, Chen, HC, Yang, LJ, Lu, SS & Lin, CW 2005, An implantable multifunctional needle type biosensor with integrated RF capability. in Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005., 1616830, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, vol. 7 VOLS, pp. 1933-1936, 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005, Shanghai, China, 05/9/1.
Chiu N-F, Wang JM, Liao CW, Chen CH, Chen HC, Yang LJ et al. An implantable multifunctional needle type biosensor with integrated RF capability. In Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005. 2005. p. 1933-1936. 1616830. (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings).
Chiu, Nan-Fu ; Wang, Jmin Min ; Liao, Cheng Wei ; Chen, Chun Hao ; Chen, Hsiao Chin ; Yang, Lung Jieh ; Lu, Shey Shi ; Lin, Chii Wann. / An implantable multifunctional needle type biosensor with integrated RF capability. Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005. 2005. pp. 1933-1936 (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings).
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