An implantable multifunctional needle type biosensor with integrated RF capability

Nan-Fu Chiu, Jmin Min Wang, Cheng Wei Liao, Chun Hao Chen, Hsiao Chin Chen, Lung Jieh Yang, Shey Shi Lu, Chii Wann Lin

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    8 Citations (Scopus)

    Abstract

    We report the development of an implantable multifunctional (glucose and cholesterol) needle type biosensor with integrated RF wireless circuitry for continuous in vivo monitoring of metabolites during short term stays in emergency room or intensive care unit. Silicon-based MEMS technologies are used for the fabrication of micro needle sensors. The whole device is covered by a biocompatible Parylene layer with opening structure at the active areas of electrodes. Electropolymerization of active biomolecules and conducting polymer provides in situ nanoscale physical entrapments of various oxidoreductases (Glucose oxidase and cholesterol oxidase) and functions as a viable matrix for the construction of micro amperometric biosensors. Hybrid CMOS fabrication processes are used to accomplish the 433 MHz ASK RF transmitter and receiver (0.18μm CMOS 1P6M process) and the data converter (0.35μm CMOS 2P4M process). We will present and discuss the detail design and the integrated system performance in this paper.

    Original languageEnglish
    Title of host publicationProceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
    Pages1933-1936
    Number of pages4
    Publication statusPublished - 2005 Dec 1
    Event2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005 - Shanghai, China
    Duration: 2005 Sep 12005 Sep 4

    Publication series

    NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
    Volume7 VOLS
    ISSN (Print)0589-1019

    Other

    Other2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005
    CountryChina
    CityShanghai
    Period05/9/105/9/4

    Keywords

    • Biosensors
    • Cholesterol
    • Glucose
    • Implantable
    • Multifunction
    • Needle type
    • Parylene
    • Polypyrrole
    • Wireless

    ASJC Scopus subject areas

    • Signal Processing
    • Biomedical Engineering
    • Computer Vision and Pattern Recognition
    • Health Informatics

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