An experimental model to evaluate the in vivo response of rat seminal vesicle to electrical stimulation

Ju Ton Hsieh, Chiang Ting Chien, Shih Ping Liu, Chau Fong Chen, Ming Kuen Lai

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

This investigation demonstrated a good model to record the pressure change of rat seminal vesicle (SV) in response to electrical stimulation (ES) of lesser splanchnic nerve (LSN) in vivo. LSN was easily identified and isolated grossly. Antegrade catheterization via the SV tail to the main lumen was performed similar to the technique of i.v. catheterization, and the pressure recording was quite satisfactory. The vesicle response to ES was frequency-dependent and reproducible. Under the conditions of 10 V and 1 ms, the maximal vesicle pressure was 81.7 ± 2.8 mmHg with 80 Hz of ES. The inhibitory response of SV to ES by clomipramine was concentration-dependent. Clomipramine (3 mg/kg) could inhibit 53% of control responses (n = 7). This experimental model is relevant to neurophysiologic and neuropharmacologic studies of SV.

Original languageEnglish
Pages (from-to)215-217
Number of pages3
JournalNeuroscience Letters
Volume204
Issue number3
DOIs
Publication statusPublished - 1996 Feb 9

Keywords

  • Clomipramine
  • Electrical stimulation
  • In vivo
  • Lesser splanchnic nerve
  • Seminal vesicle
  • Wistar rats

ASJC Scopus subject areas

  • Neuroscience(all)

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