An expedient stereoselective synthesis of spirocyclopropyl oxindoles from indolin-2-One/N-Protected indolin-2-ones and bromonitroalkenes

Suparna Roy; Kwunmin Chen

doi:10.1002/jccs.201200557

An expedient stereoselective synthesis of spirocyclopropyl oxindoles from indolin-2-One/N-Protected indolin-2-ones and bromonitroalkenes

Suparna Roy
, Kwunmin Chen^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

A direct and much simpler way was developed for the diastereoselective synthesis of spiro cyclopropan- 1,3-oxindoles from indolin-2-one/N-protected indolin-2-ones and bromonitroalkene. The fused restrained cyclopropanes were obtained with high diastereomeric ratios (upto >99:1) and in reasonable to high isolated chemical yields (upto 94%).

Original language	English
Pages (from-to)	597-604
Number of pages	8
Journal	Journal of the Chinese Chemical Society
Volume	60
Issue number	6
DOIs	https://doi.org/10.1002/jccs.201200557
Publication status	Published - 2013 Jun

Keywords

Bromonitroalkene
Cyclopropanation
Diastereoselectivity.
Oxindole

ASJC Scopus subject areas

General Chemistry

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10.1002/jccs.201200557

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title = "An expedient stereoselective synthesis of spirocyclopropyl oxindoles from indolin-2-One/N-Protected indolin-2-ones and bromonitroalkenes",

abstract = "A direct and much simpler way was developed for the diastereoselective synthesis of spiro cyclopropan- 1,3-oxindoles from indolin-2-one/N-protected indolin-2-ones and bromonitroalkene. The fused restrained cyclopropanes were obtained with high diastereomeric ratios (upto >99:1) and in reasonable to high isolated chemical yields (upto 94\%).",

keywords = "Bromonitroalkene, Cyclopropanation, Diastereoselectivity., Oxindole",

author = "Suparna Roy and Kwunmin Chen",

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AU - Chen, Kwunmin

PY - 2013/6

Y1 - 2013/6

N2 - A direct and much simpler way was developed for the diastereoselective synthesis of spiro cyclopropan- 1,3-oxindoles from indolin-2-one/N-protected indolin-2-ones and bromonitroalkene. The fused restrained cyclopropanes were obtained with high diastereomeric ratios (upto >99:1) and in reasonable to high isolated chemical yields (upto 94%).

AB - A direct and much simpler way was developed for the diastereoselective synthesis of spiro cyclopropan- 1,3-oxindoles from indolin-2-one/N-protected indolin-2-ones and bromonitroalkene. The fused restrained cyclopropanes were obtained with high diastereomeric ratios (upto >99:1) and in reasonable to high isolated chemical yields (upto 94%).

KW - Bromonitroalkene

KW - Cyclopropanation

KW - Diastereoselectivity.

KW - Oxindole

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UR - https://www.scopus.com/pages/publications/84885455553#tab=citedBy

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DO - 10.1002/jccs.201200557

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JF - Journal of the Chinese Chemical Society

IS - 6

ER -

An expedient stereoselective synthesis of spirocyclopropyl oxindoles from indolin-2-One/N-Protected indolin-2-ones and bromonitroalkenes

Abstract

Keywords

ASJC Scopus subject areas

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