An expedient stereoselective synthesis of spirocyclopropyl oxindoles from indolin-2-One/N-Protected indolin-2-ones and bromonitroalkenes

Suparna Roy, Kwunmin Chen

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A direct and much simpler way was developed for the diastereoselective synthesis of spiro cyclopropan- 1,3-oxindoles from indolin-2-one/N-protected indolin-2-ones and bromonitroalkene. The fused restrained cyclopropanes were obtained with high diastereomeric ratios (upto >99:1) and in reasonable to high isolated chemical yields (upto 94%).

Original languageEnglish
Pages (from-to)597-604
Number of pages8
JournalJournal of the Chinese Chemical Society
Volume60
Issue number6
DOIs
Publication statusPublished - 2013 Jun 1

    Fingerprint

Keywords

  • Bromonitroalkene
  • Cyclopropanation
  • Diastereoselectivity.
  • Oxindole

ASJC Scopus subject areas

  • Chemistry(all)

Cite this