### Abstract

The proportion of patients with idiopathic Parkinson’s disease (PD) who are considered demented ranges from 10% to 15%. Because dementia may affect survival in PD, the incidence rate of dementia, rather than proportion, would be a more accurate measure of disease frequency. We previously estimated the proportion of patients with PD and dementia to be 10.9% from the records of a cohort with the idiopathic form of PD in a major medical center. We reviewed the clinical records of this cohort after 4 years and 9 months to estimate the incidence rate of dementia. We identified 65 new cases of dementia from the 249 patient-records available. Using the number of person-years of follow-up for each case as the denominator, we estimated the overall incidence rate to be 69 per 1,000 person-years of observation. The mean age of this cohort was 71.4 years. The cumulative incidence of dementia increased with age. By 85 years of age, over 65% of the surviving members of the cohort were demented. The age-specific incidence rates for dementia in this cohort of PD were significantly greater than for a similarly aged cohort of healthy elderly people. The age-specific standard morbidity ratios indicated that, compared with people of similar ages, patients with PD have the highest increase in risk for dementia between ages 65 and 75.

Original language | English |
---|---|

Pages (from-to) | 1513-1517 |

Number of pages | 5 |

Journal | Neurology |

Volume | 40 |

Issue number | 10 |

Publication status | Published - 1990 Oct |

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### ASJC Scopus subject areas

- Clinical Neurology

### Cite this

*Neurology*,

*40*(10), 1513-1517.

**An estimate of the incidence of dementia in idiopathic parkinson’s disease.** / Mayeux, R.; Chen, J.; Mirabello, E.; Marder, K.; Bell, K.; Dooneief, G.; Cote, L.; Stern, Y.

Research output: Contribution to journal › Article

*Neurology*, vol. 40, no. 10, pp. 1513-1517.

}

TY - JOUR

T1 - An estimate of the incidence of dementia in idiopathic parkinson’s disease

AU - Mayeux, R.

AU - Chen, J.

AU - Mirabello, E.

AU - Marder, K.

AU - Bell, K.

AU - Dooneief, G.

AU - Cote, L.

AU - Stern, Y.

PY - 1990/10

Y1 - 1990/10

N2 - The proportion of patients with idiopathic Parkinson’s disease (PD) who are considered demented ranges from 10% to 15%. Because dementia may affect survival in PD, the incidence rate of dementia, rather than proportion, would be a more accurate measure of disease frequency. We previously estimated the proportion of patients with PD and dementia to be 10.9% from the records of a cohort with the idiopathic form of PD in a major medical center. We reviewed the clinical records of this cohort after 4 years and 9 months to estimate the incidence rate of dementia. We identified 65 new cases of dementia from the 249 patient-records available. Using the number of person-years of follow-up for each case as the denominator, we estimated the overall incidence rate to be 69 per 1,000 person-years of observation. The mean age of this cohort was 71.4 years. The cumulative incidence of dementia increased with age. By 85 years of age, over 65% of the surviving members of the cohort were demented. The age-specific incidence rates for dementia in this cohort of PD were significantly greater than for a similarly aged cohort of healthy elderly people. The age-specific standard morbidity ratios indicated that, compared with people of similar ages, patients with PD have the highest increase in risk for dementia between ages 65 and 75.

AB - The proportion of patients with idiopathic Parkinson’s disease (PD) who are considered demented ranges from 10% to 15%. Because dementia may affect survival in PD, the incidence rate of dementia, rather than proportion, would be a more accurate measure of disease frequency. We previously estimated the proportion of patients with PD and dementia to be 10.9% from the records of a cohort with the idiopathic form of PD in a major medical center. We reviewed the clinical records of this cohort after 4 years and 9 months to estimate the incidence rate of dementia. We identified 65 new cases of dementia from the 249 patient-records available. Using the number of person-years of follow-up for each case as the denominator, we estimated the overall incidence rate to be 69 per 1,000 person-years of observation. The mean age of this cohort was 71.4 years. The cumulative incidence of dementia increased with age. By 85 years of age, over 65% of the surviving members of the cohort were demented. The age-specific incidence rates for dementia in this cohort of PD were significantly greater than for a similarly aged cohort of healthy elderly people. The age-specific standard morbidity ratios indicated that, compared with people of similar ages, patients with PD have the highest increase in risk for dementia between ages 65 and 75.

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M3 - Article

C2 - 2215941

AN - SCOPUS:0025089310

VL - 40

SP - 1513

EP - 1517

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 10

ER -