An enantioselective cascade for simultaneous generation of five quaternary stereocenters from fully substituted enones

Shu Mei Yang, Ganapuram Madhusudhan Reddy, Tzu Ping Wang, Yu Sheng Yeh, Min Wang, Wen-Wei Lin

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A highly enantioselective cascade reaction for the generation of five quaternary stereocenters in one-pot operation is reported for the first time in the history of organic synthesis. Cinchona-alkaloid derived hydrogen-bonding catalyst furnished structurally complex cascade products from simple substrates in excellent yields and stereoselectivities.

Original languageEnglish
Pages (from-to)7649-7652
Number of pages4
JournalChemical Communications
Volume53
Issue number54
DOIs
Publication statusPublished - 2017 Jan 1

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Cinchona Alkaloids
Synthetic Chemistry Techniques
Stereoselectivity
Hydrogen Bonding
Hydrogen bonds
History
Catalysts
Substrates

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

An enantioselective cascade for simultaneous generation of five quaternary stereocenters from fully substituted enones. / Yang, Shu Mei; Reddy, Ganapuram Madhusudhan; Wang, Tzu Ping; Yeh, Yu Sheng; Wang, Min; Lin, Wen-Wei.

In: Chemical Communications, Vol. 53, No. 54, 01.01.2017, p. 7649-7652.

Research output: Contribution to journalArticle

Yang, Shu Mei ; Reddy, Ganapuram Madhusudhan ; Wang, Tzu Ping ; Yeh, Yu Sheng ; Wang, Min ; Lin, Wen-Wei. / An enantioselective cascade for simultaneous generation of five quaternary stereocenters from fully substituted enones. In: Chemical Communications. 2017 ; Vol. 53, No. 54. pp. 7649-7652.
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