An enantioselective cascade for simultaneous generation of five quaternary stereocenters from fully substituted enones

Shu Mei Yang, Ganapuram Madhusudhan Reddy, Tzu Ping Wang, Yu Sheng Yeh, Min Wang, Wenwei Lin

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A highly enantioselective cascade reaction for the generation of five quaternary stereocenters in one-pot operation is reported for the first time in the history of organic synthesis. Cinchona-alkaloid derived hydrogen-bonding catalyst furnished structurally complex cascade products from simple substrates in excellent yields and stereoselectivities.

Original languageEnglish
Pages (from-to)7649-7652
Number of pages4
JournalChemical Communications
Volume53
Issue number54
DOIs
Publication statusPublished - 2017 Jan 1

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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