An efficient synthesis of trisubstituted oxazoles via chemoselective o-acylations and intramolecular wittig reactions

  • Yi Ling Tsai
  • , Yu Shiou Fan
  • , Chia Jui Lee
  • , Chan Hui Huang
  • , Utpal Das
  • , Wenwei Lin*
  • *Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)

Abstract

Preparation of new types of trisubstituted oxazoles is realized via chemoselective O-acylations and intramolecular Wittig reactions with ester functionalities using in situ formed phosphorus ylides as key intermediates. A plausible reaction mechanism for this undiscovered chemistry is also proposed based on the existence of expected and rearranged isomeric oxazoles.

Original languageEnglish
Pages (from-to)10266-10268
Number of pages3
JournalChemical Communications
Volume49
Issue number87
DOIs
Publication statusPublished - 2013 Oct 8

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Catalysis
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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