An efficient synthesis of trisubstituted oxazoles via chemoselective O-acylations and intramolecular Wittig reactions

Yi Ling Tsai, Yu Shiou Fan, Chia Jui Lee, Chan Hui Huang, Utpal Das, Wenwei Lin

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Preparation of new types of trisubstituted oxazoles is realized via chemoselective O-acylations and intramolecular Wittig reactions with ester functionalities using in situ formed phosphorus ylides as key intermediates. A plausible reaction mechanism for this undiscovered chemistry is also proposed based on the existence of expected and rearranged isomeric oxazoles.

Original languageEnglish
Pages (from-to)10266-10268
Number of pages3
JournalChemical Communications
Volume49
Issue number87
DOIs
Publication statusPublished - 2013 Nov 11

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ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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