An efficient of Grignard-type procedure for the preparation of gem-diallylated compound

Kao Hsien Shen, Chun Wei Kuo, Ching Fa Yao

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An efficient and a new procedure for the conversion of various carboxylic acid derivatives into the corresponding gem-diallylated compound under mild reaction condition has been developed. The triallylaluminum mediated Grignard-type addition of carboxylic acid derivative was utilized as a key operation to affect the transformation. The procedure is operationally simple, giving good to excellent product yields for a broad range of substrates. The chemoselectivity and regioselectivity of triallylaluminum were also demonstrated.

Original languageEnglish
Pages (from-to)6348-6351
Number of pages4
JournalTetrahedron Letters
Issue number36
Publication statusPublished - 2007 Sep 3


ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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