Abstract
An efficient thiourea promoted MBH reaction of various conjugated nitroalkenes with ethyl glyoxylate was developed. The desired multifunctional products, 2-hydroxy-3-nitro-4-aryl/alkylbut-3-enoate derivatives were obtained in good to high chemical yields (56-92%) with DMAP (20 mol %) under solvent-free conditions or imidazole (100 mol %) in the presence of water.
Original language | English |
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Pages (from-to) | 9875-9879 |
Number of pages | 5 |
Journal | Tetrahedron |
Volume | 66 |
Issue number | 52 |
DOIs | |
Publication status | Published - 2010 Dec 24 |
Keywords
- Aqueous media
- Morita-Baylis-Hillman reaction
- Nitroalkenes
- Organocatalysis
- Thiourea
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry