An efficient method for the synthesis of α-arylated nitroalkanes and α-arylated hydroximoyl chlorides mediated by AlCl3

Zhijay Tu, B. Rama Raju, Tzuo Rung Liou, Veerababurao Kavala, Chun Wei Kuo, Yaochung Jang, Yu Hsuan Shih, Chun Chao Wang, Ching Fa Yao*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Friedel-Crafts alkylation of various arenes/heteroarenes to β-nitrostyrenes mediated by aluminum chloride is described. The interesting feature of this methodology pertain the formation of different products by tuning the reaction temperature. α-Arylated nitroalkanes were formed predominately at -78 °C, whereas α-arylated hydroximoyl chlorides were obtained at room temperature without any side products in high yields.

Original languageEnglish
Pages (from-to)2436-2442
Number of pages7
JournalTetrahedron
Volume65
Issue number12
DOIs
Publication statusPublished - 2009 Mar 21

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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