An efficient method for the N-bromosuccinimide catalyzed synthesis of indolyl-nitroalkanes

Chun Wei Kuo; Chun Chao Wang; Hu Lin Fang; B. Rama Raju; Veerababurao Kavala; Pateliya Mujjamil Habib; Ching Fa Yao

doi:10.3390/molecules14103952

An efficient method for the N-bromosuccinimide catalyzed synthesis of indolyl-nitroalkanes

Chun Wei Kuo, Chun Chao Wang, Hu Lin Fang, B. Rama Raju, Veerababurao Kavala, Pateliya Mujjamil Habib, Ching Fa Yao^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

An efficient and practical method for the synthesis of indolyl-nitroalkane derivatives catalyzed by N-bromosuccinimide is described. The generality of this method was demonstrated by synthesizing an array of diverse 3-substituted indole derivatives by the reaction of different β-nitrostyrenes with various substituted indoles. Simple reaction conditions accompanied by good yields of indolyl-nitroalkanes are the merits of this methodology.

Original language	English
Pages (from-to)	3952-3963
Number of pages	12
Journal	Molecules
Volume	14
Issue number	10
DOIs	https://doi.org/10.3390/molecules14103952
Publication status	Published - 2009 Oct

Keywords

Friedel-Crafts alkylation
Indolyl-nitroalkane
N-bromosuccinimide
Nitroalkenes

ASJC Scopus subject areas

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

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10.3390/molecules14103952

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title = "An efficient method for the N-bromosuccinimide catalyzed synthesis of indolyl-nitroalkanes",

abstract = "An efficient and practical method for the synthesis of indolyl-nitroalkane derivatives catalyzed by N-bromosuccinimide is described. The generality of this method was demonstrated by synthesizing an array of diverse 3-substituted indole derivatives by the reaction of different β-nitrostyrenes with various substituted indoles. Simple reaction conditions accompanied by good yields of indolyl-nitroalkanes are the merits of this methodology.",

keywords = "Friedel-Crafts alkylation, Indolyl-nitroalkane, N-bromosuccinimide, Nitroalkenes",

author = "Kuo, {Chun Wei} and Wang, {Chun Chao} and Fang, {Hu Lin} and Raju, {B. Rama} and Veerababurao Kavala and Habib, {Pateliya Mujjamil} and Yao, {Ching Fa}",

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T1 - An efficient method for the N-bromosuccinimide catalyzed synthesis of indolyl-nitroalkanes

AU - Kuo, Chun Wei

AU - Wang, Chun Chao

AU - Fang, Hu Lin

AU - Raju, B. Rama

AU - Kavala, Veerababurao

AU - Habib, Pateliya Mujjamil

AU - Yao, Ching Fa

PY - 2009/10

Y1 - 2009/10

N2 - An efficient and practical method for the synthesis of indolyl-nitroalkane derivatives catalyzed by N-bromosuccinimide is described. The generality of this method was demonstrated by synthesizing an array of diverse 3-substituted indole derivatives by the reaction of different β-nitrostyrenes with various substituted indoles. Simple reaction conditions accompanied by good yields of indolyl-nitroalkanes are the merits of this methodology.

AB - An efficient and practical method for the synthesis of indolyl-nitroalkane derivatives catalyzed by N-bromosuccinimide is described. The generality of this method was demonstrated by synthesizing an array of diverse 3-substituted indole derivatives by the reaction of different β-nitrostyrenes with various substituted indoles. Simple reaction conditions accompanied by good yields of indolyl-nitroalkanes are the merits of this methodology.

KW - Friedel-Crafts alkylation

KW - Indolyl-nitroalkane

KW - N-bromosuccinimide

KW - Nitroalkenes

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JO - Molecules

JF - Molecules

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ER -

An efficient method for the N-bromosuccinimide catalyzed synthesis of indolyl-nitroalkanes

Abstract

Keywords

ASJC Scopus subject areas

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