An efficient method for the N-bromosuccinimide catalyzed synthesis of indolyl-nitroalkanes

Chun Wei Kuo, Chun Chao Wang, Hu Lin Fang, B. Rama Raju, Veerababurao Kavala, Pateliya Mujjamil Habib, Ching Fa Yao

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

An efficient and practical method for the synthesis of indolyl-nitroalkane derivatives catalyzed by N-bromosuccinimide is described. The generality of this method was demonstrated by synthesizing an array of diverse 3-substituted indole derivatives by the reaction of different β-nitrostyrenes with various substituted indoles. Simple reaction conditions accompanied by good yields of indolyl-nitroalkanes are the merits of this methodology.

Original languageEnglish
Pages (from-to)3952-3963
Number of pages12
JournalMolecules
Volume14
Issue number10
DOIs
Publication statusPublished - 2009 Oct

Keywords

  • Friedel-Crafts alkylation
  • Indolyl-nitroalkane
  • N-bromosuccinimide
  • Nitroalkenes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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