An easy and efficient method for the synthesis of hydroximoyl chloride from nitro olefin and silyl enol ether

Ming Chung Yan, Zhijay Tu, Chunchi Lin, Ching Fa Yao

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Reactions of nitro olefin 1 with silyl enol ether 2 in the presence of TiCl4 in CH2Cl2 at 0°C gave high yields of hydroximoyl chloride 3. When the hydroximoyl chloride 3 was treated with Et3N in the presence of dipolarophile, the corresponding 2-isoxazolines were obtained.

Original languageEnglish
Pages (from-to)7991-7994
Number of pages4
JournalTetrahedron Letters
Volume43
Issue number44
DOIs
Publication statusPublished - 2002 Oct 28

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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