@article{ffefd154d9e740e980ad2d61b331ab4b,
title = "Ameliorative effect of Ruellia tuberosa L. on hyperglycemia in type 2 diabetes mellitus and glucose uptake in mouse C2C12 myoblasts",
abstract = " Ruellia tuberosa L. (RTL) exhibits a wide range of phytochemical activities, for example, on treatment of diabetes mellitus (DM), in Orient. There is, however, few study regarding the effect of RTL on glycemic-related homeostasis in type 2 DM (T2DM). We investigated the effect of RTL aqueous and ethanolic extracts on hypoglycemia in high-fat diet (HFD)-fed plus streptozotocin (STZ)-induced T2DM rats, and examined the effect of RTL on glucose uptake in tumor necrosis factor-α-induced insulin-resistant mouse C2C12 myoblasts, a mouse skeletal muscle cell line. The administration of 100 or 400 mg kg BW −1 day −1 of RTL aqueous or ethanolic extracts once a day for 4 weeks significantly ameliorated hyperglycemia, hyperinsulinemia, and the insulin resistance (IR) index in diabetic rats. RTL either aqueous or ethanolic extract at a concentration of 25–800 μg/ml significantly improved glucose uptake in insulin-resistant mouse C2C12 myoblasts, indicating inhibiting the IR in skeletal muscles. These evidences suggest that RTL ameliorates hyperglycemia in HFD/STZ-induced T2DM rats may be attributed to the alleviation of IR in skeletal muscles. ",
keywords = "C2C12 cells, hyperglycemia, insulin resistance, Ruellia tuberosa L., type 2 diabetes mellitus",
author = "Ko, {Chih Yuan} and Lin, {Ru Hai} and Zeng, {Yi Ming} and Chang, {Wen Chang} and Huang, {Da Wei} and Wu, {James Swi Bea} and Chang, {Yu Fang} and Shen, {Szu Chuan}",
note = "Funding Information: Ministry of Science and Technology of the Republic of China, Taiwan, Grant/ Award Number: MOST 104-2320-B-003- 003-MY3; Fujian Province Science and Technology Project, China, Grant/Award Number: 2018J01290; Quanzhou Science and Technology Project, China, Grant/Award Number: 2017Z016 and 2018Z107; Strait Exchanges Postdoctoral Funding Schemes of Fujian Province, China , and academic funding of the Second Affiliated Hospital of Fujian Medical University (serial No. BSH001) Funding Information: The authors would like to thank the Ministry of Science and Technology of the Republic of China, Taiwan, for financially supporting this research under contract No. MOST 104-2320-B-003-003-MY3, and partly funded by the Fujian Province Science and Technology Project, Funding Information: China, under contract No. 2018J01290, and the Quanzhou Science and Technology Project, China, under contract No. 2017Z016 and No. 2018Z107. This article was also subsidized by the National Taiwan Normal University (NTNU), Taiwan, R.O.C, and Strait Exchanges Postdoctoral Funding Schemes of Fujian Province, China, and academic funding of the Second Affiliated Hospital of Fujian Medical University (serial No. BSH001).",
year = "2018",
month = nov,
day = "1",
doi = "10.1002/fsn3.840",
language = "English",
volume = "6",
pages = "2414--2422",
journal = "Food Science and Nutrition",
issn = "2048-7177",
publisher = "John Wiley and Sons Ltd",
number = "8",
}