Advances in biomagnetic research using high- Tc superconducting quantum interference devices

Hong-Chang Yang*, Herng-Er Horng, Shieh-Yueh Yang, Shu-Hsien Liao

*Corresponding author for this work

    Research output: Contribution to journalReview articlepeer-review

    12 Citations (Scopus)


    This review reports the advances of biomagnetic research using high- T c superconducting quantum interference devices (SQUIDs). It especially focuses on SQUID-detected magnetocardiography (MCG), magnetically labeled immunoassays (MLIs) as well as nuclear magnetic resonance and imaging (NMR/MRI). The progress in MCG that scientists have made and the encountered challenges are discussed here. This study includes the early detection of the electromagnetic change in cardiac activity in animal studies of hypercholesterolemic rabbits, which suggests the possibility of early diagnosis of cardiac disease in clinical applications. The progress on MLIs using measurements of remanence, magnetic relaxation and magnetic susceptibility reduction is presented. The wash-free immunomagnetic reduction shows both high sensitivity and high specificity. NMR/MRI of high spectral resolution and of high signal-to-noise ratio are addressed and discussed. The proton-phosphate J-coupling of trimethyl phosphate ((CH3)3PO4) in one shot in microtesla fields is demonstrated. The prospects of biomagnetic applications are addressed.

    Original languageEnglish
    Article number093001
    JournalSuperconductor Science and Technology
    Issue number9
    Publication statusPublished - 2009 Sep 10

    ASJC Scopus subject areas

    • Ceramics and Composites
    • Condensed Matter Physics
    • Metals and Alloys
    • Electrical and Electronic Engineering
    • Materials Chemistry


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