TY - JOUR
T1 - Acute responses of bone specific and related markers to maximal eccentric exercise of the knee extensors and flexors in young men
AU - Huang, Tsang Hai
AU - Lin, Jung Charng
AU - Ma, Mi Chia
AU - Yu, Tsung
AU - Chen, Trevor C.
N1 - Funding Information:
The authors thank Mr Ming-Ju Lin and Miss Jui-Hsin Lin for their assistance with the data collection. We also thank Miss Jae Cody for her editorial assistance in English. This research was supported by a grant from the Ministry of Science and Technology (MOST 103-2410-H-006-096-MY2), TAIWAN, to Dr. H.T. Huang, and Dr. T.C. Chen was also the recipient of grants from both the “MOST (MOST105-2410-H-003-052-MY3)” and the Higher Education Sprout Project by the Ministry of Education (MOE), Taiwan.
Publisher Copyright:
© 2020, International Society of Musculoskeletal and Neuronal Interactions. All rights reserved.
PY - 2020/6
Y1 - 2020/6
N2 - Objectives: The present study determined time-course changes in plasma bone-specific and -related markers following a bout of maximal eccentric contractions (MaxEC) of bilateral knee extensors (KE) and flexors (KF). Methods: Sedentary young men (n=30) performed a bout of 10 sets of 10 MaxEC (30°/s) of KE and KF with each leg, respectively. Maximal voluntary isometric contraction (MVC) torque, muscle soreness (SOR), plasma creatine kinase (CK) activity, insulin, leptin, tumor necrosis factor-α (TNF-α), undercarboxylated-osteocalcin (ucOCN), carboxy-terminal crosslinking telopeptide of type I collagen (CTX-1) and procollagen type I N-terminal propeptide (P1NP) concentrations were measured from before to 7 days after MaxEC. Results: Significant changes in MVC (KE: -28%, KF: -38%), SOR and plasma CK activity (peak: 39,163 IU/L) following MaxEC were evident (P<0.05) compared to baseline. Plasma leptin (17%) concentrations decreased at 1 day after MaxEC. In bone related markers, plasma ucOCN concentrations (20%) increased at 7 days after MaxEC, and plasma CTX-1 concentrations decreased at 2, 4 and 7 days after MaxEC (6~7%; P<0.05). Conclusion: These results demonstrate that a lean effect of bone generation and an enhanced energy anabolism can be induced by a single bout of MaxEC.
AB - Objectives: The present study determined time-course changes in plasma bone-specific and -related markers following a bout of maximal eccentric contractions (MaxEC) of bilateral knee extensors (KE) and flexors (KF). Methods: Sedentary young men (n=30) performed a bout of 10 sets of 10 MaxEC (30°/s) of KE and KF with each leg, respectively. Maximal voluntary isometric contraction (MVC) torque, muscle soreness (SOR), plasma creatine kinase (CK) activity, insulin, leptin, tumor necrosis factor-α (TNF-α), undercarboxylated-osteocalcin (ucOCN), carboxy-terminal crosslinking telopeptide of type I collagen (CTX-1) and procollagen type I N-terminal propeptide (P1NP) concentrations were measured from before to 7 days after MaxEC. Results: Significant changes in MVC (KE: -28%, KF: -38%), SOR and plasma CK activity (peak: 39,163 IU/L) following MaxEC were evident (P<0.05) compared to baseline. Plasma leptin (17%) concentrations decreased at 1 day after MaxEC. In bone related markers, plasma ucOCN concentrations (20%) increased at 7 days after MaxEC, and plasma CTX-1 concentrations decreased at 2, 4 and 7 days after MaxEC (6~7%; P<0.05). Conclusion: These results demonstrate that a lean effect of bone generation and an enhanced energy anabolism can be induced by a single bout of MaxEC.
KW - Bone metabolism
KW - Delayed onset muscle soreness
KW - Lengthening contractions
KW - Muscle damage
KW - Plasma creatine kinase activity
UR - http://www.scopus.com/inward/record.url?scp=85085676893&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85085676893&partnerID=8YFLogxK
M3 - Article
C2 - 32481236
AN - SCOPUS:85085676893
SN - 1108-7161
VL - 20
SP - 206
EP - 215
JO - Journal of Musculoskeletal Neuronal Interactions
JF - Journal of Musculoskeletal Neuronal Interactions
IS - 2
ER -
