Abstract
The highly enantioselective conjugate addition of a variety of arylboronic acids to β-nitroacrylates is reported to provide optically active α-aryl β-nitropropionates in up to 70% yields and >99.5% ee's, which are useful building blocks for preparing chiral β 2 -amino acids. The applicability of this transformation is demonstrated by converting 3aa into the β 2 -amino acid 5 and transforming 3ap to β-amino ester 7 via reduction and reductive N-alkylation. The latter compound is a precursor for preparing ent-ipatasertib.
Original language | English |
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Pages (from-to) | 12184-12191 |
Number of pages | 8 |
Journal | Journal of Organic Chemistry |
Volume | 83 |
Issue number | 19 |
DOIs | |
Publication status | Published - 2018 Oct 5 |
ASJC Scopus subject areas
- Organic Chemistry