A Water-Soluble Rhenium(I) Catalyst for the Regio- And Stereoselective C(sp2)-H Alkenylation of N-Pyridyl-/ N-Pyrimidylindole and the N-H Alkenylation of N-Pyrimidylaniline Derivatives with Ynamides

Sundaramoorthi Sarathkumar, Veerababurao Kavala, Ching Fa Yao*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

A water-soluble and low-valent rhenium(I) catalyst for the C2 alkenylation of N-pyridyl/N-pyrimidylindole derivatives with ynamides under mild conditions using water as the solvent has been described. The reaction of N-pyridyl/N-pyrimidyl indole with the ynamide afforded the C2-Z-selective alkenylation derivative as the sole product, and the reactions of N-pyrimidylanilines delivered the corresponding N-alkenylated product rather than the expected C-H alkenylation products in high yields under the same conditions.

Original languageEnglish
Pages (from-to)1960-1965
Number of pages6
JournalOrganic Letters
Volume23
Issue number6
DOIs
Publication statusPublished - 2021 Mar 19

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'A Water-Soluble Rhenium(I) Catalyst for the Regio- And Stereoselective C(sp<sup>2</sup>)-H Alkenylation of N-Pyridyl-/ N-Pyrimidylindole and the N-H Alkenylation of N-Pyrimidylaniline Derivatives with Ynamides'. Together they form a unique fingerprint.

Cite this