A versatile and practical method for regioselective synthesis of polysubstituted furanonaphthoquinones

Zong Ze Wu, Yeong Jiunn Jang, Chia Jui Lee, Yen Te Lee, Wenwei Lin

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

An efficient and attractive synthesis of a series of novel poly-functionalized phosphorus zwitterions was achieved via three-component reactions of the corresponding functional nucleophiles, aldehydes, and Bu 3P in the presence of acidic promoter. These polysubstituted zwitterions could regioselectively undergo further transformations to synthetically important furanonaphthoquinones and related products via the intramolecular Wittig reaction. These methods could have potential application in synthetic and pharmaceutical chemistry for its facilitation and easily accessible commercial materials.

Original languageEnglish
Pages (from-to)828-834
Number of pages7
JournalOrganic and Biomolecular Chemistry
Volume11
Issue number5
DOIs
Publication statusPublished - 2013 Feb 7

    Fingerprint

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this