Abstract
The development of optical organic nanoparticles (NPs) is desirable and widely studied. However, most organic dyes are water-insoluble such that the derivatization and modification of these dyes are difficult. Herein, we demonstrated a simple platform for the fabrication of organic NPs designed with emissive properties by loading ten different organic dyes (molar masses of 479.1–1081.7 g/mol) into water-soluble polymer nanosponges composed of poly(styrene-alt-maleic acid) (PSMA). The result showed a substantial improvement over the loading of commercial dyes (3.7–50% loading) while preventing their spontaneous aggregation in aqueous solutions. This packaging strategy includes our newly synthesized organic dyes (> 85% loading) designed for OPVs (242), DSSCs (YI-1, YI-3, YI-8), and OLEDs (ADF-1–3, and DTDPTID) applications. These low-cytotoxicity organic NPs exhibited tunable fluorescence from visible to near-infrared (NIR) emission for cellular imaging and biological tracking in vivo. Moreover, PSMA NPs loaded with designed NIR-dyes were fabricated, and photodynamic therapy with these dye-loaded PSMA NPs for the photolysis of cancer cells was achieved when coupled with 808 nm laser excitation. Indeed, our work demonstrates a facile approach for increasing the biocompatibility and stability of organic dyes by loading them into water-soluble polymer-based carriers, providing a new perspective of organic optoelectronic materials in biomedical theranostic applications.
Original language | English |
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Article number | 311 |
Journal | Journal of Nanobiotechnology |
Volume | 20 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2022 Dec |
Keywords
- Fluorescence imaging
- Multiphoton microscopy
- Near-infrared red
- Optoelectronic material
- Photodynamic therapy
- Polymer
- Theranostic
ASJC Scopus subject areas
- Bioengineering
- Medicine (miscellaneous)
- Molecular Medicine
- Biomedical Engineering
- Applied Microbiology and Biotechnology
- Pharmaceutical Science
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A universal strategy for the fabrication of single-photon and multiphoton NIR nanoparticles by loading organic dyes into water-soluble polymer nanosponges
Yang, L. (Creator), Liu, Y. (Creator), Cho, C. (Creator), Chen, Y. (Creator), Yang, C. (Creator), Lu, Y. (Creator), Zhang, Z. (Creator), Tsai, Y. (Creator), Chin, Y. (Creator), Yu, J. (Creator), Pan, H. (Creator), Jiang, W. (Creator), Chia, Z. (Creator), Huang, W. (Creator), Chiu, Y. (Creator), Sun, C. (Creator), Huang, Y. (Creator), Chen, L. (Creator), Wong, K. (Creator), Huang, H. (Creator), Chen, C. (Creator), Chang, Y. J. (Creator), Huang, C. (Creator), Liu, T. (Creator), Liu, Y. (Creator), Tsai, Y. (Creator) & Huang, Y. (Creator), figshare, 2022
DOI: 10.6084/m9.figshare.c.6083480.v1, https://springernature.figshare.com/collections/A_universal_strategy_for_the_fabrication_of_single-photon_and_multiphoton_NIR_nanoparticles_by_loading_organic_dyes_into_water-soluble_polymer_nanosponges/6083480/1
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A universal strategy for the fabrication of single-photon and multiphoton NIR nanoparticles by loading organic dyes into water-soluble polymer nanosponges
Yang, L. (Creator), Liu, Y. (Creator), Cho, C. (Creator), Chen, Y. (Creator), Yang, C. (Creator), Lu, Y. (Creator), Zhang, Z. (Creator), Tsai, Y. (Creator), Chin, Y. (Creator), Yu, J. (Creator), Pan, H. (Creator), Jiang, W. (Creator), Chia, Z. (Creator), Huang, W. (Creator), Chiu, Y. (Creator), Sun, C. (Creator), Huang, Y. (Creator), Chen, L. (Creator), Wong, K. (Creator), Huang, H. (Creator), Chen, C. (Creator), Chang, Y. J. (Creator), Huang, C. (Creator), Liu, T. (Creator), Liu, Y. (Creator), Tsai, Y. (Creator) & Huang, Y. (Creator), figshare, 2022
DOI: 10.6084/m9.figshare.c.6083480, https://springernature.figshare.com/collections/A_universal_strategy_for_the_fabrication_of_single-photon_and_multiphoton_NIR_nanoparticles_by_loading_organic_dyes_into_water-soluble_polymer_nanosponges/6083480
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