Abstract
A new Iri-antennary, galactoside-capped gallamide dendritic anchor with thiolate focal group is synthesized via click chemistry. The highly hydrophilic dendron was efficiently anchored onto the surface of CdSe/ZnS core/shell nanoparticles in a covalent fashion, as evidenced by 1H NMR spectrum of the resultant nanohybrid with intact core fluorescent property. The water-soluble nano-hybrid was found smoothly and selectively uptaken by lung cancer cells enriched with membrane-bound asialoprotein receptors in 2-3 h. as evidenced by confocal microscopic analysis. Furthermore, cancer cells that are undergoing active mitosis also tend to uptake the nanohybrids efficiently and remain sustainable in serum-containing medium for several days, which shed light on its application as a photodynamic drug carrier for apoptosis study.
Original language | English |
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Pages (from-to) | 527-540 |
Number of pages | 14 |
Journal | Advanced Functional Materials |
Volume | 18 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2008 Feb 22 |
ASJC Scopus subject areas
- General Chemistry
- General Materials Science
- Condensed Matter Physics