A triantennary dendritic galactoside-capped nanohybrid with a ZnS/CdSe nanoparticle core as a hydrophilic, fluorescent, multivalent probe for metastatic lung cancer cells

Chien Tien Chen*, Yogesh S. Munot, Santosh B. Salunke, Yi Ching Wang, Ruo Kai Lin, Chun Cheng Lin, Chia Chun Chen, Y. Hsin Liu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)

Abstract

A new Iri-antennary, galactoside-capped gallamide dendritic anchor with thiolate focal group is synthesized via click chemistry. The highly hydrophilic dendron was efficiently anchored onto the surface of CdSe/ZnS core/shell nanoparticles in a covalent fashion, as evidenced by 1H NMR spectrum of the resultant nanohybrid with intact core fluorescent property. The water-soluble nano-hybrid was found smoothly and selectively uptaken by lung cancer cells enriched with membrane-bound asialoprotein receptors in 2-3 h. as evidenced by confocal microscopic analysis. Furthermore, cancer cells that are undergoing active mitosis also tend to uptake the nanohybrids efficiently and remain sustainable in serum-containing medium for several days, which shed light on its application as a photodynamic drug carrier for apoptosis study.

Original languageEnglish
Pages (from-to)527-540
Number of pages14
JournalAdvanced Functional Materials
Volume18
Issue number4
DOIs
Publication statusPublished - 2008 Feb 22

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

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