@article{d6d5a7edd9af47488ddef46f9dc38b4a,
title = "A theoretical framework to determine the optimal centrifugation angle for separation of plasma from blood samples",
abstract = "The separation of blood plasma by centrifugation can be accelerated by placement of the sample at an angle relative to the direction of the centrifugal force. This geometric effect, which has been known for a century, is due to the Boycott effect, while the enhanced sedimentation of red blood cells (RBCs) in tilted vessels can be attributed to buoyancy-induced convection. Moreover, flow instability would invalidate the traditional predictive model and weaken separation enhancement. While current model considers only the geometric effect, by considering the buoyancy-induced convection and flow instability, we devise a model for the first time enabling the prediction of the optimal tilt angle to achieve the highest separation efficiency. A comparison of our theoretical prediction with the available experimental data shows good agreement. A sensitivity analysis is also conducted to investigate the influence of variation in blood samples on the physical parameters.",
keywords = "Blood plasma separation, Boycott effect, Centrifugation",
author = "Lee, {Ming Jing} and Chang, {Yu Jen} and Cheng, {Che Jung} and Yeh, {Yi Chun} and Chen, {Chien Fu} and Chou, {Yi Ju}",
note = "Funding Information: We gratefully acknowledge the support of the Taiwan Ministry of Science and Technology (MOST) the Thermal Science and Fluid Dynamic Program under grant no. MOST 109-2221-E-002-028-MY3 . Funding Information: Yi-Ju Chou received a Ph.D. degree in Environmental Fluid Mechanics at Stanford University with a minor in Computational and Mathematical Engineering. He is currently a professor in the Institute of Applied Mechanics at National Taiwan University. His research focuses on the development and application of novel numerical methods to study complex flow phenomena that span a wide range of spatial and temporal scales. He received Youth Scholar Grant Award (2016) from the National Science and Technology Council, Taiwan and Young Scholar Award (2021) from the Society of Theoretical and Applied Mechanics, Taiwan. Funding Information: Chien-Fu Chen is a Professor at the Institute of Applied Mechanics at National Taiwan University, Taiwan. He obtained his Ph.D. at the Institute of Applied Mechanics from National Taiwan University in 2007. He received the Outstanding Research Award (2022), Futuretech Award (2020), Futuretech Breakthrough Award (2019), and Youth Scholar Grant Award (2018) from the National Science and Technology Council, Taiwan. Prof. Chen{\textquoteright}s research focuses on miniaturized systems utilizing micro/nanomaterials for biomedical point-of-care diagnostic applications. Publisher Copyright: {\textcopyright} 2023 Elsevier B.V.",
year = "2023",
month = apr,
day = "16",
doi = "10.1016/j.sna.2023.114234",
language = "English",
volume = "353",
journal = "Sensors and Actuators, A: Physical",
issn = "0924-4247",
publisher = "Elsevier",
}