A simple and facile route for the synthesis of 2H-1,4-benzoxazin-3-(4H)- ones via reductive cyclization of 2-(2-nitrophenoxy)acetonitrile adducts in the presence of Fe/acetic acid

Chintakunta Ramesh; B. Rama Raju; Veerababurao Kavala; Chun Wei Kuo; Ching Fa Yao

doi:10.1016/j.tet.2010.11.095

A simple and facile route for the synthesis of 2H-1,4-benzoxazin-3-(4H)- ones via reductive cyclization of 2-(2-nitrophenoxy)acetonitrile adducts in the presence of Fe/acetic acid

Chintakunta Ramesh
, B. Rama Raju
, Veerababurao Kavala
, Chun Wei Kuo
, Ching Fa Yao^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

A simple route for the synthesis of 1,4-benzoxazin-3-(4H)-ones is described herein. This method involves the reductive cyclization of 2-(2-nitrophenoxy) acetonitrile adducts in the presence of Fe/acetic acid in good to excellent yields. This system was compatible with various other functional groups.

Original language	English
Pages (from-to)	1187-1192
Number of pages	6
Journal	Tetrahedron
Volume	67
Issue number	6
DOIs	https://doi.org/10.1016/j.tet.2010.11.095
Publication status	Published - 2011 Feb 11

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tet.2010.11.095

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A simple and facile route for the synthesis of 2H-1,4-benzoxazin-3-(4H)- ones via reductive cyclization of 2-(2-nitrophenoxy)acetonitrile adducts in the presence of Fe/acetic acid. / Ramesh, Chintakunta; Raju, B. Rama; Kavala, Veerababurao et al.
In: Tetrahedron, Vol. 67, No. 6, 11.02.2011, p. 1187-1192.

Research output: Contribution to journal › Article › peer-review

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abstract = "A simple route for the synthesis of 1,4-benzoxazin-3-(4H)-ones is described herein. This method involves the reductive cyclization of 2-(2-nitrophenoxy) acetonitrile adducts in the presence of Fe/acetic acid in good to excellent yields. This system was compatible with various other functional groups.",

author = "Chintakunta Ramesh and Raju, \{B. Rama\} and Veerababurao Kavala and Kuo, \{Chun Wei\} and Yao, \{Ching Fa\}",

note = "Funding Information: Financial support for this work by the National Science Council of the Republic of China and the National Taiwan Normal University ( 99T3030-2 ) is gratefully acknowledged. ",

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AU - Ramesh, Chintakunta

AU - Raju, B. Rama

AU - Kavala, Veerababurao

AU - Kuo, Chun Wei

AU - Yao, Ching Fa

N1 - Funding Information: Financial support for this work by the National Science Council of the Republic of China and the National Taiwan Normal University ( 99T3030-2 ) is gratefully acknowledged.

PY - 2011/2/11

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AB - A simple route for the synthesis of 1,4-benzoxazin-3-(4H)-ones is described herein. This method involves the reductive cyclization of 2-(2-nitrophenoxy) acetonitrile adducts in the presence of Fe/acetic acid in good to excellent yields. This system was compatible with various other functional groups.

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A simple and facile route for the synthesis of 2H-1,4-benzoxazin-3-(4H)- ones via reductive cyclization of 2-(2-nitrophenoxy)acetonitrile adducts in the presence of Fe/acetic acid

Abstract

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