A simple and facile route for the synthesis of 2H-1,4-benzoxazin-3-(4H)- ones via reductive cyclization of 2-(2-nitrophenoxy)acetonitrile adducts in the presence of Fe/acetic acid

Chintakunta Ramesh, B. Rama Raju, Veerababurao Kavala, Chun Wei Kuo, Ching Fa Yao

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

A simple route for the synthesis of 1,4-benzoxazin-3-(4H)-ones is described herein. This method involves the reductive cyclization of 2-(2-nitrophenoxy) acetonitrile adducts in the presence of Fe/acetic acid in good to excellent yields. This system was compatible with various other functional groups.

Original languageEnglish
Pages (from-to)1187-1192
Number of pages6
JournalTetrahedron
Volume67
Issue number6
DOIs
Publication statusPublished - 2011 Feb 11

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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