Abstract
A simple route for the synthesis of 1,4-benzoxazin-3-(4H)-ones is described herein. This method involves the reductive cyclization of 2-(2-nitrophenoxy) acetonitrile adducts in the presence of Fe/acetic acid in good to excellent yields. This system was compatible with various other functional groups.
| Original language | English |
|---|---|
| Pages (from-to) | 1187-1192 |
| Number of pages | 6 |
| Journal | Tetrahedron |
| Volume | 67 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2011 Feb 11 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry
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Cite this
Ramesh, C., Raju, B. R., Kavala, V., Kuo, C. W., & Yao, C. F. (2011). A simple and facile route for the synthesis of 2H-1,4-benzoxazin-3-(4H)- ones via reductive cyclization of 2-(2-nitrophenoxy)acetonitrile adducts in the presence of Fe/acetic acid. Tetrahedron, 67(6), 1187-1192. https://doi.org/10.1016/j.tet.2010.11.095